Results 51 to 60 of about 824,262 (318)

Cost-Effectiveness Analysis [PDF]

, 2019
Abstract Cost-effectiveness analysis (CEA) is a form of economic evaluation concerned with efficiency: that is, with achieving the most for the resources (“value for money”). This chapter explains the appeal and relevance of CEA and describes its use in localized and strategic decision-making.
Lauer, Jeremy, Bertram, Melanie, Morton, Alec   +2 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analyzing operating and support costs for Air Force aircraft [PDF]

Journal of Defense Analytics and Logistics, 2018
Purpose – Recent legislation resulted in an elevation of operating and support (O&S) costs’ relative importance for decision-making in Department of Defense programs.
Scott C. Hewitson, Jonathan D. Ritschel, Edward White, Gregory Brown   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Costos directos de la artritis reumatoide temprana en el primer año de atención: simulación de tres situaciones clínicas en un hospital universitario de tercer nivel en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2009
Introducción. En Colombia se desconoce cuál es la carga derivada de las enfermedades reumatológicas crónicas de forma global y en las diferentes esferas del sistema de salud. La artritis reumatoide es una de las enfermedades más frecuentes en su clase y,
Gerardo Quintana, Claudia Mora, Andrés González, Jorge Díaz Díaz   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Costs associated with adverse events among acute patients

BMC Health Services Research, 2017
Background The aim of this study was to analyse the additional treatment costs of acute patients admitted to a Danish hospital who suffered an adverse event (AE) during in-hospital treatment. Methods A matched case-control design was utilised.
Jakob Kjellberg, Rasmus Trap Wolf, Marie Kruse, Susanne R. Rasmussen, Jesper Vestergaard, Kent J. Nielsen, Kurt Rasmussen   +6 more
doaj   +1 more source

Cost analysis of informal care: estimates from a national cross-sectional survey in Sweden

BMC Health Services Research, 2021
Background Over the past decades, informal care has increased in most OECD-countries. Informal care is costly to caregivers and to society in the form of lost income and direct costs of providing care.
Björn Ekman, Kevin McKee, Joana Vicente, Lennart Magnusson, Elizabeth Hanson   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Indirect Costs and Cost-Effectiveness Analysis

Value in Health, 2006
This article examines the methodological implications of the societal perspective in cost-effectiveness analyses in which the costs of health-care interventions are defined as the sums of direct and indirect costs. In the model of cost-effectiveness analysis in which the planner distributes patients among many treatments for many illnesses, the ...
openaire   +2 more sources