Results 61 to 70 of about 254,400 (263)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Costs associated with adverse events among acute patients

BMC Health Services Research, 2017
Background The aim of this study was to analyse the additional treatment costs of acute patients admitted to a Danish hospital who suffered an adverse event (AE) during in-hospital treatment. Methods A matched case-control design was utilised.
Jakob Kjellberg, Rasmus Trap Wolf, Marie Kruse, Susanne R. Rasmussen, Jesper Vestergaard, Kent J. Nielsen, Kurt Rasmussen   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Cost-of-illness study in a retrospective cohort of patients with dementia in Lima, Peru

Dementia & Neuropsychologia
Dementia is a major cause of dependency and disability among older persons, and imposes huge economic burdens. Only a few cost-of-illness studies for dementia have been carried out in middle and low-income countries.
Nilton Custodio, David Lira, Eder Herrera-Perez, Liza Nuñez del Prado, José Parodi, Erik Guevara-Silva, Sheila Castro-Suarez, Rosa Montesinos   +7 more
doaj   +1 more source

An econometric analysis of motorway renewal costs in Germany [PDF]

This paper analyses the cost bahaviour of motorway renewal costs with the aim to derive an estimate of marginal infrastructure costs per vehicle-km of trucks as part of optimal road user charges.
Heike Link
core  

Hospital performance: costs of acute admitted patients in public hospitals in 2011–12 [PDF]

, 2015
Some public hospitals spend nearly twice as much money as others to provide similar services to similar groups of patients. Overview Hospitals account for a large share of the funds Australia spends on the health sector each year. In 2011–12, about 30%
National Health Performance Authority
core  

Costs of Parkinson's Disease and Antiparkinsonian Pharmacotherapy: An Italian Cohort Study [PDF]

, 2010
Objective: Antiparkinsonian pharmacotherapy is costly and the determinants of drug costs in Parkinson's disease (PD) have been poorly investigated. The objective of this study was to investigate the costs of PD and antiparkinsonian drugs in an Italian ...
Katia Longo, Oertel, Wolfgang H., Bötzel, Kai, Yaroslav Winter, Karla Eggert, Paolo Barone, Balzer-Geldsetzer, Monika, Kai Boetzel, Dodel, Richard, Longo, Katia, Jens P. Reese, Wolfgang H. Oertel, Sonja von Campenhausen, Giuseppe Spiga, Campenhausen, Sonja von, Winter, Yaroslav, Richard Dodel, Reese, Jens P., Barone, Paolo, Spiga, Giuseppe, Eggert, Karla, Monika Balzer-Geldsetzer   +21 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Costs of nursing procedures/interventions: an integrative literature review [PDF]

Revista Brasileira de Enfermagem
Objectives: to analyze the scientific production of nurses regarding the costs of procedures/interventions performed by nursing professionals. Methods: integrative literature review with a sample of 17 primary articles selected from the CINAHL, Scopus ...
Paula Buck de Oliveira Ruiz, Caroline Rife Nobrega, Cínthia Prates Vigna, Antônio Fernandes Costa Lima   +3 more
doaj   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source