Results 61 to 70 of about 3,520,446 (404)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The variation of acute treatment costs of trauma in high-income countries

BMC Health Services Research, 2012
Background In order to assist health service planning, understanding factors that influence higher trauma treatment costs is essential. The majority of trauma costing research reports the cost of trauma from the perspective of the receiving hospital ...
Willenberg Lynsey, Curtis Kate, Taylor Colman, Jan Stephen, Glass Parisa, Myburgh John   +5 more
doaj   +1 more source

Decision Analysis and Cost-Effectiveness Analysis [PDF]

Seminars in Spine Surgery, 2009
Healthcare decision-making can be complex, often requiring decision makers to weigh serious trade-offs, consider patients' values, and incorporate evidence in the face of uncertainty. Medical decisions are made implicitly by clinicians and other decision-makers on a daily basis. Decisions based largely on personal experience are subject to many biases.
Hilary F, Ryder, Christine, McDonough, Anna N A, Tosteson, Jon D, Lurie   +3 more
openaire   +2 more sources

Evaluating cost taxonomies for information systems management [PDF]

, 2006
The consideration of costs, benefits and risks underpin many Information System (IS) evaluation decisions. Yet, vendors and project-champions alike tend to identify and focus much of their effort on the benefits achievable from the adoption of new ...
Ahmad Ghoneim, Anandarajan, Ballantine, Ballantine, David, Earl, Heo, Hirschheim, Hochstrasser, Irani, Irani, Irani, Irani, Irani, Kaplan, Legris, Milis, Peter E.D. Love, Powell, Primose, Remenyi, Renkema, Ryan, Sillince, Wheatley, Zahir Irani   +25 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluating the impact of new anticoagulants in the hospital setting

Pharmacy Practice, 2011
The short-comings of current anticoagulants have led to the development of newer, albeit more expensive, oral alternatives.Objective: To explore the potential impact the new anticoagulants dabigatran and rivaroxaban in the local hospital setting, in ...
Braidy N, Bui K, Bajorek B
doaj  

Costing and Cost Analysis in Randomized Controlled Trials [PDF]

PharmacoEconomics, 2009
This article provides an overview of the central issues regarding cost valuation and analysis for a decision maker's evaluation of costing performed within randomized controlled trials (RCTs). Costing involves specific choices for valuation and analysis that involve trade-offs.
Daniel, Polsky, Henry, Glick
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Costs associated with adverse events among acute patients

BMC Health Services Research, 2017
Background The aim of this study was to analyse the additional treatment costs of acute patients admitted to a Danish hospital who suffered an adverse event (AE) during in-hospital treatment. Methods A matched case-control design was utilised.
Jakob Kjellberg, Rasmus Trap Wolf, Marie Kruse, Susanne R. Rasmussen, Jesper Vestergaard, Kent J. Nielsen, Kurt Rasmussen   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source