Results 141 to 150 of about 28,882 (293)

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

Cancer Science, EarlyView.
Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda   +11 more
wiley   +1 more source

Translocation effects on regional and local population viability and connectivity

Conservation Biology, EarlyView.
Abstract Translocations and reintroductions aim to improve the viability of isolated populations and promote connectivity for large carnivores. However, there is no established framework for assessing their success. We used the Eurasian lynx (Lynx lynx) in western and central Europe to assess the impact of translocations on the viability of six ...
Eva Sánchez Arribas, Aimara Planillo, Joe Premier, Tobias Kürschner, Elisa Belotti, Christine Breitenmoser‐Würsten, Luděk Bufka, Rok Černe, Thomas Engleder, Urša Fležar, Tomislav Gomerčić, Miha Krofel, Tereza Mináriková, Paolo Molinari, Simona Poláková, Kateřina Poledníková, Hubert Potočnik, Magda Sindičić, Ira Topličanec, Kristina Vogt, Josefa Volfová, Sybille Wölfl, Fridolin Zimmermann, Marco Heurich, Stephanie Kramer‐Schadt, Anja Molinari‐Jobin   +25 more
wiley   +1 more source

Psychometric framework for coexistence with large carnivores

Conservation Biology, EarlyView.
Abstract Human–carnivore coexistence is essential for biodiversity conservation, yet measuring the attitudes and behaviors that support it remains methodologically challenging. We developed psychometric scales to assess willingness to coexist with carnivores and the underlying beliefs of this coexistence through an iterative expert elicitation process ...
Benjamin Ghasemi, Gerard Kyle, Tara Teel, Rebeca Niemiec, Kevin Crooks, Jenny Anne Glikman, Neil H. Carter, John A. Vucetich, Michelle L. Lute, Stewart Breck, Beatrice Frank, Dana Hoag, Jonathan Salerno, Lily M. van Eeden, Jeremy T. Bruskotter   +14 more
wiley   +1 more source

Shedding light on the dark: Does artificial illumination affect mammal activity at waterholes in sub‐Saharan Africa?

Conservation Science and Practice, EarlyView.
We experimentally evaluated the effects of artificial lighting on mammal visitation patterns at waterholes in north‐central Namibia using motion‐activated camera traps across two dry seasons. Lighting had minimal effects on most species, although gemsboks increased use of artificially lit waterholes and lions reduced nocturnal activity at illuminated ...
Jessica R. Patterson, Stéphanie Périquet‐Pearce, James C. Beasley   +2 more
wiley   +1 more source

“Leave it to the experts”: Misleading narratives drive public voting on a wildlife protection ballot initiative

Conservation Science and Practice, EarlyView.
Abstract As public values toward wildlife shift, some stakeholders are turning towards ballot initiatives to promote their values in management decision making. While there has been a growing body of literature on public perceptions toward wildlife management issues more broadly, less is known about what influences public voting behavior on wildlife ...
Rebecca M. Niemiec, Mireille Gonzalez, Jenna Brager, Lori Kogan   +3 more
wiley   +1 more source

From Dumb Wireless Sensors to Smart Networks using Network Coding

, 2006
The vision of wireless sensor networks is one of a smart collection of tiny, dumb devices. These motes may be individually cheap, unintelligent, imprecise, and unreliable.
Dimakis, A. G., Petrovic, D., Ramchandran, K.   +2 more
core   +1 more source

Genetic and Ecological Management of Pacific Salmon Fisheries for the 21st Century

Fisheries Management and Ecology, EarlyView.
ABSTRACT Based on ecological adaptation theory, tremendous effort is being spent on measures that are eliminating salmon hatcheries and fishing opportunities with the intention of protecting wild runs deemed to be of particular genetic importance to the survival of the species.
Randall E. Brummett, Ian G. Cowx, Devin M. Bartley   +2 more
wiley   +1 more source

Diets, dominance hierarchies, and kleptoparasitism drive asymmetrical interactions between wolves and cougars. [PDF]

Proc Natl Acad Sci U S A
Binder W, Ruprecht JS, Rabe J, Metz MC, Hutchinson R, Stahler DR, Levi T.   +6 more
europepmc   +1 more source

World Health Organization classification of tumours of the breast 6th edition 2026

Histopathology, EarlyView.
The 6th edition of the World Health Organization Classification of Breast Tumours introduces changes based on recent advances in our understanding of breast biology, developments in diagnostic modalities, identification of specific molecular targets and new treatment regimes.
Cecily Quinn, Puay Hoon Tan, Kimberly H Allison, Edi Brogi, Sunil R Lakhani, Stuart J Schnitt, Stephen B Fox, Shabnam Jaffer, Aysegul Sahin, Roberto Salgado, Anna Sapino, Ernest Kwasi Adjei, Katherine Geiersbach, Thomas H Helbich, Matteo Lambertini, Christos Sotiriou, Jennelle C Hodge, Joseph D Khoury, Bharat Rekhi, Ales Ryska, Gary Tse, Andrew Field, Harshima Wijesinghe, Pavitratha Puspanathan, Christine Giesen, Blanca Iciar Indave Ruiz, Ian Ellis, Dilani Lokuhetty, WCT Standing Editorial Board, Wendy Cooper, Michael Eden, Andrew Field, Vicky Goh, Jennelle C. Hodge, James Kench, Joseph D. Khoury, Katia Leite, Zhiyong Liang, Daichi Maeda, George Netto, Bharat Rekhi, Miguel Reyes Mugica, Brian Rous, Ales Ryska, Shahin Sayed, Antonia Sepulveda, Chanjuan Shi, Gary Tse   +47 more
wiley   +1 more source