Results 171 to 180 of about 28,882 (293)

Accurate and fast clade assignment via deep learning and frequency chaos game representation. [PDF]

open access: yesGigascience, 2022
Avila Cartes J   +5 more
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang   +14 more
wiley   +1 more source

Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W

open access: yesProtein Science, Volume 35, Issue 6, June 2026.
Abstract The tumor suppressor protein p53 plays a crucial role in cell cycle regulation. In approximately 50% of all tumors, mutations in p53 are observed. Although the top hot spot mutations impair DNA binding, other mutations affect the thermal stability of the protein, leading to its rapid denaturation in physiological conditions.
Jason Stahlecker   +9 more
wiley   +1 more source

Automated Imaging as an Adjunct to Serum and Clinical Biomarkers: A New Validated Prediction Tool for Metastatic Castration-Resistant Prostate Cancer. [PDF]

open access: yesClin Cancer Res
Morris MJ   +10 more
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini   +7 more
wiley   +1 more source

Fatal Toxoplasma gondii COUG strain infections in southern sea otters (Enhydra lutris nereis): New insight on contributing factors and parasite serotyping. [PDF]

open access: yesPLoS One
Sinnott DM   +10 more
europepmc   +1 more source

ABCG2 Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids. [PDF]

open access: yesGenes (Basel), 2022
Gochenauer AE   +5 more
europepmc   +1 more source

Narratives, Networks, and the Evolution of Paracrises: Evidence From X (Twitter) Discourse on the Adidas SL72 Campaign

open access: yesJournal of Contingencies and Crisis Management, Volume 34, Issue 2, June 2026.
ABSTRACT This study examined the developmental processes of paracrises and reputational threats amplified on social media, through a case study of the Adidas SL72 sneaker campaign, a faux pas‐type paracrisis. Unlike crises that directly threaten organizational survival, paracrises are reputational threats that primarily impact corporate social ...
Da Eun Song, Dan Ro, Hyunmi Baek
wiley   +1 more source

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