Results 191 to 200 of about 28,882 (293)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, Volume 20, Issue 5, Page 1323-1346, May 2026.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu   +12 more
wiley   +1 more source

Detection of prions from spiked and free-ranging carnivore feces. [PDF]

open access: yesSci Rep
Inzalaco HN   +10 more
europepmc   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

open access: yesAdvanced Science, Volume 13, Issue 27, 13 May 2026.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li   +25 more
wiley   +1 more source

A parasite odyssey: An RNA virus concealed in Toxoplasma gondii. [PDF]

open access: yesVirus Evol
Gupta P   +9 more
europepmc   +1 more source

Does Your Classmatesʼ Early Childhood Education Experience Affect Your Non‐Cognitive/Socio‐Emotional Skills?

open access: yesAsia &the Pacific Policy Studies, Volume 13, Issue 2, May 2026.
ABSTRACT We investigate whether having more classmates with ECE experience affects junior high school studentsʼ non‐cognitive/socio‐emotional skills. We draw on panel data from the China Education Panel Survey (CEPS) and leverage the exogenous variation in classroom ECE experience composition brought by the random assignment of students when they ...
Yuhe Guo, Chengfang Liu, Yalin Tang
wiley   +1 more source

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