Results 141 to 150 of about 94,849 (289)

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

Fluorescent Supramolecular Gels Based on D‐Sorbitol Derivatives

Small, EarlyView.
Sugar‐based fluorescent low‐molecular‐weight gelators (LMWGs) DNapS, DBTDS, and MCumS, prepared by a green, scalable route, form supramolecular gels in water, organic, and deep eutectic solvents. MCumS yields solvent‐dependent nanofibrous networks and viscoelastic injectable eutectogels.
Emmanuel Odella, Miryam Criado‐Gonzalez, Rodrigo A. Ponzio, David Mecerreyes, Matías L. Picchio, Daniele Mantione   +5 more
wiley   +1 more source

Thermoresponsive Complex Coacervates as Advanced Carriers for Cell‐Laden Liquid‐Core Capsules for Biomedical Applications

Small, EarlyView.
A thermoresponsive complex coacervate is engineered to transport liquid‐core capsules loaded with human adipose‐derived stem cells, forming modular, hierarchically organized tissue‐forming units. This injectable platform enables precise spatial control while maintaining high cell viability, offering a versatile and bioinspired strategy for minimally ...
Luís P. G. Monteiro, Mariana Carreira, Julien Es Sayed, Marleen Kamperman, João M. M. Rodrigues, João Mano   +5 more
wiley   +1 more source

A novel sulfur‐containing photoinitiator based on benzophenone derivatives for rapid photopolymerization

Smart Molecules, EarlyView.
This study develops a series of unimolecular photoinitiators, BP‐S1‐5, by incorporating hydrogen‐donating groups into a benzophenone framework. This method reduces the reliance on co‐initiators, and enables BP‐S1‐5 with efficient photoinitiation and excellent molding capability.
Yu Li, Wenzheng Li, Saihe Yang, Lu Li, Shikun Song, Yuting Tang, Han Han, Zhenyue Duan, Yangyang Xin, Jiangli Fan, Pengzhong Chen, Xiaojun Peng   +11 more
wiley   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

PEGylated Chitosan Nanoparticles: Engineering Multifunctional Platforms for Targeted Cervical and Lung Cancer Treatment

Cancer Science, EarlyView.
Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani, Nazim Nasir, Shadma Wahab, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation. [PDF]

Pharm Sci Adv
Mustafa YF.
europepmc   +1 more source

Wash-Free Multi-Target Super-Resolution Microscopy With Photocaged DNA Labels. [PDF]

Angew Chem Int Ed Engl
Photocaged DNA labels enable wash‐free multi‐target super‐resolution microscopy. A single type of DNA–fluorophore imager strand hybridizes to two orthogonal light‐responsive docking strands, whose hybridization state can be modulated with light from “ON” to “OFF” and vice versa.
Kaltenschnee N, Dietz MS, Kessler LF, Li Y, Kaufmann J, Heckel A, Heilemann M.   +6 more
europepmc   +3 more sources