Results 131 to 140 of about 91,068 (301)

Macrocycle-Assisted Cooperative Fe³⁺ Coordination and Fluorescence Regulation in a Coumarin-Functionalized Calix[4]arene. [PDF]

ACS Omega
Güngör Ö, Taşci N, Ünaldı AŞ, Durmuş M.   +3 more
europepmc   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Evaluation of the Potential Anti-Inflammatory Effect of a New Coumarin-Quinoline Hybrid in LPS-Induced Neuroinflammation. [PDF]

Pharmaceuticals (Basel)
Shehata OHM, Abdelaziz E, Ali H, Elmongy EI, Binsuwaidan R, Ibrahim WM, El-Gamasy S, Tantawy El Sayed IE.   +7 more
europepmc   +1 more source

The Human Gut Microbiome Metabolizes Diverse Bioactive Coumarins via α,β-Unsaturated Lactone Reduction. [PDF]

J Nat Prod
Mingolelli G, Bashatwah RM, Jurek MJ, Chauvin IM, Orjala J, Riley AP, Burdette JE, Henke MT.   +7 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Physiologic and molecular response of Fusarium oxysporum f. sp. zingiberi to ginger autotoxins. [PDF]

PLoS One
Zhang Y, Guo H, Xu Y, Chen X, Zhang M, Li N, Gera A.   +6 more
europepmc   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation. [PDF]

Pharm Sci Adv
Mustafa YF.
europepmc   +1 more source

St John's Wort (Hypericum perforatum) Oil on Immune Response, Growth Performance and Bacterial Resistance Against Lactococcus garvieae Pathogen in Rainbow Trout (Oncorhynchus mykiss)

Journal of Fish Diseases, EarlyView.
ABSTRACT In this study, we investigated the immunomodulatory effects of St. John's Wort (Hypericum perforatum) oil on the growth performance, immune responses and resistance against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss). The plant oil was incorporated into feeds at concentrations of 1, 3, and 5 g kg−1, designated as K1, K3, and K5,
Soner Bilen, Mustafa Karga, Osman Nezih Kenanoğlu, Ertuğrul Terzi   +3 more
wiley   +1 more source

Quality formation in <i>Peucedanum praeruptorum</i> dunn: metabolite biosynthesis, geoherbal variation, and early bolting regulation. [PDF]

Front Plant Sci
Chen R, Wang W, Chen C, Xu Z, Pu J, Xu P.   +5 more
europepmc   +1 more source