Results 151 to 160 of about 94,849 (289)

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, EarlyView.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

Coumarin-Based Prodrugs: Therapeutic Promise or Still Confined to Preclinical Exploration? [PDF]

Pharmaceutics
Chavez Alvarez AC, Moreau E.
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Synthesis of some novel coumarin-based heterocycles, elucidation of their antifungal behavior, molecular docking and computational studies. [PDF]

Sci Rep
Ismail MF, Salem MAI, Marzouk MI, Mahmoud NFH, Abdullah NH, Gouda MAS.   +5 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Photoresponsive Polymers for Debonding-on-Demand Pressure-Sensitive Adhesives. [PDF]

ACS Appl Mater Interfaces
Raji IO, Dhopatkar N, Ribelli TG, Saldanha M, Fromel M, Bartholomew E, Konkolewicz D.   +6 more
europepmc   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Effects of Donor Rigidity on Coumarin Delayed Emission: New Tricks from Old Materials. [PDF]

J Phys Chem Lett
Paredis S, Cardeynaels T, Kuila S, Deckers J, Lathouwers A, Van Landeghem M, Vandewal K, Danos A, Monkman AP, Champagne B, Maes W.   +10 more
europepmc   +1 more source

St John's Wort (Hypericum perforatum) Oil on Immune Response, Growth Performance and Bacterial Resistance Against Lactococcus garvieae Pathogen in Rainbow Trout (Oncorhynchus mykiss)

Journal of Fish Diseases, EarlyView.
ABSTRACT In this study, we investigated the immunomodulatory effects of St. John's Wort (Hypericum perforatum) oil on the growth performance, immune responses and resistance against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss). The plant oil was incorporated into feeds at concentrations of 1, 3, and 5 g kg−1, designated as K1, K3, and K5,
Soner Bilen, Mustafa Karga, Osman Nezih Kenanoğlu, Ertuğrul Terzi   +3 more
wiley   +1 more source

Coumarin compounds as fungicidal agents against powdery mildew and rust in cereals. [PDF]

Sci Rep
Rząd K, Nucia A, Szwaczko K, Matwijczuk A, Okoń S.   +4 more
europepmc   +1 more source