Results 171 to 180 of about 91,068 (301)

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents. [PDF]

open access: yesChemMedChem
Carneiro A   +8 more
europepmc   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais   +5 more
wiley   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu   +7 more
wiley   +1 more source

Counterion Effects Enable Divergent Pd‐Catalyzed Carbonylative Cyclization of Amide‐Tethered o‐Alkynylphenols

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
The catalytic carbonylation of alkynes is a powerful route to heteroaromatic scaffolds, yet achieving regioselectivity remains challenging. Herein, we report a divergent carbonylative cyclization of 2‐alkynylphenol derivatives that affords either coumarins (6‐endo‐dig) or 2‐coumaranones (5‐exo‐dig) by tuning the palladium‐based catalytic system. Pd(OAc)
Aleksandr Voronov   +11 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

open access: yesAdvanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Multifunctional Bio‐Based Packaging for Perishable Foods: Structural Design, Scalable Fabrication, and Versatile Applications

open access: yesAdvanced Materials, Volume 38, Issue 33, 12 June 2026.
An overview of design principles and scalable fabrication strategies for multifunctional bio‐based packaging. Radiative cooling films, modified‐atmosphere films/membranes, active antimicrobial/antioxidant platforms, intelligent optical/electrochemical labels, and superhydrophobic surfaces are co‐engineered from material chemistry to mesoscale structure
Lei Zhang   +6 more
wiley   +1 more source

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