Results 151 to 160 of about 50,342 (276)

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review. [PDF]

Basic Clin Pharmacol Toxicol
Dos Santos IM, de Oliveira Rocha JL, de Alencar Filho EB, Silva FS.   +3 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Nutritional composition, antioxidant and antimicrobial properties of Opuntia ficus-indica (L) Miller cladodes and fruits. [PDF]

Plant Foods Hum Nutr
Santana IVR, do Nascimento Ozaki GE, Tulini FL.   +2 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Diastereodivergent and Enantioselective Organocatalytic Synthesis of Spiro-Fused Coumarins via [4+2] Cycloadditions. [PDF]

Org Lett
Hidalgo-León R, Trujillo-Sierra J, Sansano JM, Cossío FP, Cozar A, Retamosa MG.   +5 more
europepmc   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Comparative analysis of metabolites in different <i>Areca</i> inflorescence tissues based on spatial metabolomics. [PDF]

Front Plant Sci
Wen X, Li P, Zhang L, Li H, Yang F.
europepmc   +1 more source

St John's Wort (Hypericum perforatum) Oil on Immune Response, Growth Performance and Bacterial Resistance Against Lactococcus garvieae Pathogen in Rainbow Trout (Oncorhynchus mykiss)

Journal of Fish Diseases, EarlyView.
ABSTRACT In this study, we investigated the immunomodulatory effects of St. John's Wort (Hypericum perforatum) oil on the growth performance, immune responses and resistance against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss). The plant oil was incorporated into feeds at concentrations of 1, 3, and 5 g kg−1, designated as K1, K3, and K5,
Soner Bilen, Mustafa Karga, Osman Nezih Kenanoğlu, Ertuğrul Terzi   +3 more
wiley   +1 more source

The targeted metabolomic profile of laticifers in rubber tree

Journal of Integrative Plant Biology, EarlyView.
Targeted metabolomic profiling of rubber tree (Hevea brasiliensis) laticifers identified metabolites that were reprogramming by domestication, revealed active isoprenoid metabolism in the laticifers, and discovered loci with potential biosynthetic applications, supporting the potential of developing laticifers as bioreactors for production of valuable ...
Xiaomin Deng, Shuguang Yang, Qiang Gao, Yanling Chen, Xia Zeng, Minjing Shi, Shaohua Wu, Weimin Tian, Xuchu Wang, Jinquan Chao   +9 more
wiley   +1 more source