Results 91 to 100 of about 3,138,133 (293)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Other title: September Council meeting ; progress report
, 1949 "September 1949."SEPTEMBER COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Agriculture and Livestock -- Assessment and Taxation -- Proposal 5, County Fees -- Proposal 11, Hearings on Application ...
Kansas Legislature. Legislative Council.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Other title: May Council meeting, progress report
, 1958 "May 1958."MAY COUNCIL MEETING -- Status of Council Work -- Legislative Committee on Economy and Efficiency - Fourth Interim Report -- COUNCIL ACTION ON PROPOSALS -- Educational Survey - Pro. No. 7 -- Charges for Care in State Hospitals - Pro. No.
Kansas Legislature. Legislative Council.
core +1 more source
El municipio constitucional en la España de 1812
Revista de Derecho Político, 2012 El artículo tiene por objeto el estudio de la institución municipal en la Constitución de Cádiz de 1812. Principia la exposición analizando el modelo de municipio propugnado por gobierno bonapartista caracterizado por el acendrado centralismo contrario a
Enrique Orduña Rebollo
doaj +1 more source
Other title: March Council meeting, progress report
, 1962 "March 1962."MARCH COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Agriculture and Livestock -- Soil Conservation - Proposal No.
Kansas Legislature. Legislative Council.
core +1 more source
Other title: November Council meeting, progress report
, 1959 "November 1959."NOVEMBER COUNCIL MEETING -- Status of Council Work - New Proposals -- COUNCIL ACTION ON PROPOSALS -- Code of Civil Procedure - Proposal No. 13 -- Intangible Tax Law - Proposal No.
Kansas. Legislature. Legislative Council.
core +1 more source
Other title: September council meeting, progress report
, 1959 "September 1959."SEPTEMBER COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Charitable, Benevolent and Penal Institutions -- Parole of Inmates of Penal Institutions -- Education -- Educational ...
Kansas. Legislature. Legislative Council.
core +1 more source
Zbornik Radova Pravnog Fakulteta u Splitu, 2014 The authors of this paper analyse administrative adjudication process brought in by Amendments to the Administrative Dispute Act of 2012. Namely, when the new Administrative Dispute act was brought in and enacted at the beginning of 2012, meant that for ...
Marko Šikić, Frane Staničić
doaj