Results 81 to 90 of about 3,313,431 (294)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Other title: September Council meeting : progress report
, 1947 "September 1947."SEPTEMBER COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Agriculture and Livestock -- Assessment and Taxation -- Proposal 5, Tax-Exempt Government Property -- Proposal 8 ...
Kansas. Legislature. Legislative Council.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Other title: May Council meeting, progress report
, 1959 "May 1959."MAY COUNCIL MEETING COUNCIL ASSIGNMENTS Proposals Submitted by the Legislature Proposals 1-7 Proposals Introduced at the May Session No. 8 - Departmental Rules and Regulations No. 9 - Collection of Sales Tax on Motor Vehicles No. 10 -
Kansas. Legislature. Legislative Council.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Other title: May Council meeting, progress report
, 1962 "May 1962."MAY COUNCIL MEETING -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Assessment and Taxation -- Gross Earnings Tax for Schools - Proposal No. 16 -- Charitable, Benevolent, and Penal Institutions -- Penal Institutions - Proposal
Kansas. Legislature. Legislative Council.
core +1 more source
El municipio constitucional en la España de 1812
Revista de Derecho Político, 2012 El artículo tiene por objeto el estudio de la institución municipal en la Constitución de Cádiz de 1812. Principia la exposición analizando el modelo de municipio propugnado por gobierno bonapartista caracterizado por el acendrado centralismo contrario a
Enrique Orduña Rebollo
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
, 1944 "A special meeting of the legislative council was held on June 8 and 9 for the consideration of recommendations for the reorganization of the elementary school district system"--Page 1.<br>Cover title and at head of title: Progress report, June ...
Kansas Legislature. Legislative Council. Research Department.
core +1 more source