Results 61 to 70 of about 1,504,105 (267)
THE STATE OF THE MINING INDUSTRY AND THE PROGRESS OF THE REBOLUTIONARY MOVEMENT IN SULUKTA AT TNE END OF XIX AND AT THE BEGINNING OF XX CENTURY [PDF]
Vestnik Issyk-Kulʹskogo universitetaThe article deals with the coal mining in the southwestern region at the end of the 19th and beginning of the 20th centuries, its development, the formation of a mining cooperative, the social situation of our people, a lifestyle based on coal mining ...
Seitmuratova A. Zh.
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE ROLE OF THE PRESIDENCY IN THE FUNCTIONING OF THE EUROPEAN UNION ROMANIAN PRESIDENCY OF THE EU COUNCIL - CHALLENGES AND OPPORTUNITIES [PDF]
Challenges of the Knowledge Society, 2019 This year, for the first time in the history of its membership in the European Union, Romania exercises the rotating presidency of the Council of the European Union.
Dragoș – Adrian BANTAȘ
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Vox Patrum, 2014 Sobór Nicejski nie położył kresu kontrowersji ariańskiej. Po soborze nastąpił długi okres walki o recepcję chrystologii nicejskiej. Kontrowersja stała się przedmiotem zainteresowania cesarza, ponieważ postrzegano ją jako zagrożenie dla jedności ...
Oleksandr Kashchuk
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source