Results 31 to 40 of about 1,520,404 (308)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Robust anticipation of continuous steering actions from electroencephalographic data during simulated driving

open access: yesScientific Reports, 2021
Driving a car requires high cognitive demands, from sustained attention to perception and action planning. Recent research investigated the neural processes reflecting the planning of driving actions, aiming to better understand the factors leading to ...
Giovanni M. Di Liberto   +6 more
doaj   +1 more source

Is diversity changing religious education? Religion, diversity and education in today’s Europe [PDF]

open access: yes, 2009
The study of religious diversity as part of public education has become an important issue in recent times across Europe and in the wider international arena.
Jackson, Robert
core  

Teaching about religions in the public sphere: European policy initiatives and the interpretive approach [PDF]

open access: yes, 2008
This paper charts a policy shift within international and European inter-governmental institutions towards advocating the study of religions (or the study of religions and beliefs) in European publicly funded schools.
Jackson, Robert
core   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

Redesigning the European Court of Human Rights: Embeddedness as a Deep Structural Principle of the European Human Rights Regime [PDF]

open access: yes, 2008
The European Court of Human Rights (ECHR) is the crown jewel of the world’s most advanced international system for protecting civil and political liberties. In recent years, however, the ECHR has become a victim of its own success. The Court now faces a
Helfer, Laurence R.
core   +4 more sources

Data protection in relation to transborder information sharing for network security and criminal justice purposes [PDF]

open access: yes, 2010
Between November 2012 and September 2013, Joseph A. Cannataci responded to a brief commissioned by the Directorate General of Human Rights and Rule of Law of the Council of Europe.
Cannataci, Joseph A.   +2 more
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

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