Results 51 to 60 of about 170,962 (256)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Московский журнал международного права, 2013 The article indicated by the problems of the International Procedural Law paradigm; provided the author’s concept of a broad understanding of the Council of Europe procedural law.
T. A. Antsupova
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Наукові записки НаУКМА: Юридичні науки, 2020 An overlap in the activities of the Council of Europe and the EU as regards the protection of human rights leads to cross-fertilisation of both systems.
Pavlo Pushkar
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Council of Europe and Democratic Security
Politikon, 2016 The concept of security has remained in the shadows of the ‘three pillars’ of the Council of Europe (CoE) until 2015 when the annual report of its Secretary General presented the term ‘democratic security’.
Max Steuer
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Studia Universitatis Babeş-Bolyai. Studia Europaea, 2015 The national minorities in Europe are perceived by the Council of Europe as elements that preserve and promote the cultural wealth of Europe. For their protection, the Council of Europe created instruments. The national minorities have also been part of
Romana SĂLĂGEANU
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Politeja, 2020 The Condition of Local Democracy in Poland in Light of the Council of Europe’s Standards and the European Charter of Local Self-Government Compliance Monitoring Mechanism. A Political Dimension In the article, I will discuss a model and a mechanism of
Mirosław Natanek
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source