Results 31 to 40 of about 207,627 (301)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Safeguarding human rights on the net [PDF]
, 2016 The Council of Europe works with governments, the private sector, civil society and other actors to shape the Internet as a safe and open environment where freedom of expression, freedom of assembly and association, diversity, culture and education can ...
Council of Europe
core
Council of Europe: Heritage and Beyond. Strasbourg: Council of Europe Publishing, 2009.
E-RPH, 2015 Celia Martínez Yáñez
doaj
European Journal of Risk RegulationThe Council of Europe has very recently adopted the Framework Convention on Artificial Intelligence and Human Rights, Democracy and the Rule of Law. This article provides an initial analysis of the CoE AI Convention.
Vladislava Stoyanova
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Victims : support and assistance. [PDF]
, 2007 Justice depends not only an states' ability to prosecute the perpetrators of a crime, but also on their capacity to restore the situation of victims.
Council of Europe.
core
Scientific Reports, 2021 Driving a car requires high cognitive demands, from sustained attention to perception and action planning. Recent research investigated the neural processes reflecting the planning of driving actions, aiming to better understand the factors leading to ...
Giovanni M. Di Liberto +6 more
doaj +1 more source
The Common European Framework of Reference: Transcending perspectives
Moderna Språk, 2022 Stressing a balanced and constrained interplay between the individual and the collective and tending towards transdisciplinarity as a consequence, a socio-cognitive perspective prevails in second language acquisition research (Larsen-Freeman 2018 ...
Ariadna Strugielska +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source