Results 91 to 100 of about 169,119 (354)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

"The European Council in Theoretical Perspectives: The Principals on a Fusion Path" [PDF]

open access: yes, 2007
Since its creation in the 1970s no other institution has formed the European Union so intensively and continuously like the European Council. This “key institution” of the European Union takes nearly all major decisions for the EU and the institutional ...
Schafer, Verena., Wessels, Wolfgang
core  

The Influence of the EU Council Presidency on National Coordination Mechanisms for European Agenda [PDF]

open access: yesRomanian Journal of European Affairs, 2017
This article examines the degree to which holding the Presidency of the Council of the EU (Presidency) influences CEE countries’ national systems of European affairs coordination.
Johana Galušková
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The EU Council Presidency Dilemma: an Historical Institutionalist Interpretation [PDF]

open access: yes
The aim of this article is to demonstrate the usefulness of taking into account the variable of EU institutional development when analysing the consequences of EU membership. Using an historical institutionalist perspective, the article examines the path
Ana Mar Fernàndez
core  

Old Rules, New Game: Decision-making in the Council of Ministers after the 2004 Enlargement. CEPS Special Reports, March 2007 [PDF]

open access: yes, 2007
Drawing on an extensive data set and a large number of interviews with senior officials, diplomats and other practitioners, this report investigates the 32 months leading up to and following the enlargement of the EU in May 2004, i.e. from September 2001
Hagemann, Sara.   +1 more
core  

Democracy or Oligarchy? Unequal Representation of Income Groups in European Institutions

open access: yesPolitics and Governance, 2020
In this study we examine the representation of income groups in two EU-level institutions, the Council and the European Parliament. We find that the political positions of these institutions, and especially of the Council, are always on the right ...
Zoe Lefkofridi, Nathalie Giger
doaj   +1 more source

More on the EU Council conclusions on OA

open access: yes, 2007
Žiga Turk, Council on Scientific Information in the Digital Age: Too Little Too Late, <em> Growth, jobs and more </em> , November 27, 2007.  Turk is the Slovenian minister for growth.  Excerpt: <b> Update </b> (11/29/07). Also see the EurActiv article on Turk&#39;s assessment of the Council conclusions. <b> Update &
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Current Challenges regarding the International Refugee Law, with focus on EU Policies and EU Co-operation with UNHCR. CEPS Paper on Liberty and Security in Europe No. 59, September 2013 [PDF]

open access: yes, 2013
From an examination of the instruments of the Common European Asylum System (CEAS) and related policy measures regarding border surveillance and migration management, two interrelated issues stand out as particularly sensitive: Access to asylum and ...
Guild, Elspeth, Moreno-Lax, Violeta
core  

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