Results 111 to 120 of about 169,119 (354)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Connected Coalition Formation and Voting Power in the Council of the European Union: An Endogenous Policy Approach. EIPA Working Paper 99/W/05 [PDF]

open access: yes, 1999
Resorting to political economy approaches, this paper attempts to associate the industrial structure in the European Union (EU) to the coalition formation process between European member states.
Bilal, Sanoussi, Hosli, Madeleine O.
core  

Public Voting Data of the Council of the EU

open access: yes, 2021
This data set contains the voting behaviour of EU member states in public votes of the Council of the EU from 2010 to 2021. Particular attention was given to the following issues: How often did the Council adopt decision by consensus despite voting under
Ondarza, Nicolai von, Stiftung Wissenschaft und Politik   +1 more
core   +1 more source

The EU Council Presidency: Billboard for the European Integration?

open access: yesCzech Journal of International Relations, 2008
The EU Council Presidency is considered a very influential and suitable tool for domestic communication of European integration and its agenda. The article analyses the last ten EU Council Presidencies and their impact on public support to the key ...
Petr Kaniok
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Politics of Decision Making in the Council of the EU

open access: yesPolitikon: The IAPSS Journal of Political Science, 2015
This paper examines the decision making of the Council of the European Union to gain insight into how consensus decisions emerge and how they change power allocations and influence the behavior of negotiators and voting blocs.  It surveys rationalist and non-rationalist accounts of consensus decisions in the Council and concludes that rationalist ...
openaire   +4 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

COUNCIL REGULATION (EU) 2019/1111: NEW PROGRESS IN INTERNATIONAL CHILD ABDUCTIONS [PDF]

open access: yesChallenges of the Knowledge Society
Council Regulation (EU) 2019/1111, recently entered into force, brought significant progress for EU Member States in the specific area of international child abductions.
Anca Magda VOICULESCU
doaj  

Voting system of the European Union (EU) Council and the future of the EU (I)

open access: yesSfera Politicii, 2020
An analyze of decision-making process in EU Council, starting from its history, its voting mechanisms and its relations with the other EU institutions which often involve co-decision.
Gabriel Catalan
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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