Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
An Assessment of the Polish Presidency of the Council Through the Lens of the EU VAT System
Financial Law ReviewThe Presidency of the Council is a unique event for each member of the European Union. The effectiveness of the presidency is a determinant of the position both in the Union and in the country.
Marek Bełdzikowski
doaj +1 more source
The EU's Accession to the European Convention on Human Rights: An International Law Perspective [PDF]
, 2015 Article 6(2) of the Treaty on European Union establishes that the Union “shall accede to the European Convention for the Protection of Human Rights and Fundamental Freedoms.” In early 2013, negotiators of the 47 Council of Europe member states and the ...
Odermatt, J.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Influence of the EU Council Presidency on National Coordination Mechanisms for European Agenda [PDF]
Romanian Journal of European Affairs, 2017 This article examines the degree to which holding the Presidency of the Council of the EU (Presidency) influences CEE countries’ national systems of European affairs coordination.
Johana Galušková
doaj
ECB Decision-making and the Status of the Eurogroup in an Enlarged EMU [PDF]
This paper analyses the link between forthcoming EU enlargement and selected aspects of EU institutional reforms, namely decision making rules in the European Central Bank and the status of the Eurogroup. It argues that some earlier arguments calling for
Wojciech Paczynski
core
On the new economic philosophy of crisis management in the European Union [PDF]
, 2012 This essay attempts to go beyond presenting the bits and pieces of still ongoing crisis management in the EU. Instead it attempts at finding the ‘red thread’ behind a series of politically improvised decisions.
Acemoglu D. +24 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Shaping of a Policy Framework for the Wider Europe. CEPS Policy Brief No. 39, September 2003 [PDF]
, 2003 [From the Introduction]. With the enlargement of the EU from 15 to 25, the new Wider Europe debate – interpreted in the broad sense as in this paper – rises high up on the EU agenda, complementing the draft Constitution prepared by the European ...
Emerson, Michael.
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source