Results 71 to 80 of about 966,835 (308)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
‘Facultative’ and ‘Functional Mixity’ in light of the Principle of Partial and Imperfect Conferral. College of Europe Research Paper in Law 03/2019 [PDF]
, 2019 The concept of ‘facultative mixity’ as first coined by Allan Rosas3 has sparked a much heated debate.4 Is it a matter of political expediency in the EU Council to decide on the mixed nature, or not, of a given agreement in so far as it falls within ...
Govaere, Inge
core
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
The Influence of the EU Council Presidency on National Coordination Mechanisms for European Agenda [PDF]
Romanian Journal of European Affairs, 2017 This article examines the degree to which holding the Presidency of the Council of the EU (Presidency) influences CEE countries’ national systems of European affairs coordination.
Johana Galušková
doaj
It wasn't me! The Luxembourg Court orders on the EU-Turkey refugee deal. CEPS Policy Insights No. 2017-15/April 2017 [PDF]
, 2017 It wasn’t me! This was in essence what the European Council, alongside the Council and the Commission, answered to the Court of Justice of the European Union (CJEU) when asked about the authorship of the EU-Turkey Statement.
Carrera, Sergio +2 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Democracy or Oligarchy? Unequal Representation of Income Groups in European Institutions
Politics and Governance, 2020 In this study we examine the representation of income groups in two EU-level institutions, the Council and the European Parliament. We find that the political positions of these institutions, and especially of the Council, are always on the right ...
Zoe Lefkofridi, Nathalie Giger
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source