Results 101 to 110 of about 6,858,530 (350)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A discrete Stochastic Korovkin theorem

International Journal of Mathematics and Mathematical Sciences, 1991
In this article we give a sufficient condition for the pointwise −− in the first mean Korovkin property on B0(P), the space of stochastic processes with real state space and countable index set Γ and bounded first moments.
George A. Anastassiou
doaj   +1 more source

Characterizing Subgroups of Compact Abelian Groups

, 2004
We prove that every countable subgroup of a compact metrizable abelian group has a characterizing set. As an application, we answer several questions on maximally almost periodic (MAP) groups and give a characterization of the class of (necessarily MAP ...
Dikranjan, Dikran, Kunen, Kenneth
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Common Solution for a Finite Family of Equilibrium Problems, Inclusion Problems and Fixed Points of a Finite Family of Nonexpansive Mappings in Hadamard Manifolds [PDF]

Sahand Communications in Mathematical Analysis
In this paper, we present an iterative algorithm and prove that the sequence generated by this algorithm converges strongly to a common solution of a finite family of equilibrium problems, the quasi-variational inclusion problem and  the set of common ...
Prashant Patel, Rahul Shukla
doaj   +1 more source

Stationary countable dense random sets [PDF]

Advances in Applied Probability, 2000
We study the probability theory of countable dense random subsets of (uncountably infinite) Polish spaces. It is shown that if such a set is stationary with respect to a transitive (locally compact) group of symmetries then any event which concerns the random set itself (rather than accidental details of its construction) must have probability zero or ...
openaire   +2 more sources

Addendum to "countable algebra and set existence axioms"

Annals of Pure and Applied Logic, 1985
Proof. (1) + (2) is given on p. 163 of [l]. (2) j (3) is trivial. (3) j (1). We shall use Lemma 3.2 of [l]. Let f, g :N +-N be given with Vi, j ((f(i) # go’)) and f, g both one-to-one. Let R, = Q[x,, : n EN] be the polynomial ring over the rationals with
H. Friedman, S. G. Simpson, Rick L. Smith   +2 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source