Results 91 to 100 of about 6,858,530 (350)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2010 We introduce a new monotone hybrid iterative scheme for finding a common element of the set of common fixed points of a countable family of nonexpansive multivalued maps, the set of solutions of variational inequality problem, and the set of the ...
Watcharaporn Cholamjiak, Suthep Suantai
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Application of mixture of exponentials distributions for modeling queuing systems
Lietuvos Matematikos Rinkinys, 2008 The article considers approximation of positive distribution functions by mixture of exponentials distributions. This approximation enables to model non-markovian queuing systems by Markov process with continuous time and countable set of states.
Mindaugas Šnipas +1 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Rings of functions which are discontinuous on a finite set with countable range [PDF]
, 2023 Achintya Singha +3 more
openalex +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On the Set of Fixed Points and Periodic Points of Continuously Differentiable Functions
International Journal of Mathematics and Mathematical Sciences, 2013 In recent years, researchers have studied the size of different sets related to the dynamics of self-maps of an interval. In this note we investigate the sets of fixed points and periodic points of continuously differentiable functions and show that ...
Aliasghar Alikhani-Koopaei
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Countable algebra and set existence axioms
Annals of Pure and Applied Logic, 1983 On considere des axiomes d'existence d'ensemble formules dans le contexte des sous-systemes faibles d'arithmetique d'ordre 2. On etudie des theoremes algebriques de 2 sortes: existence et unicite des fermetures algebriques denombrables; existence et ...
H. Friedman +2 more
semanticscholar +1 more source