Results 81 to 90 of about 4,296,132 (289)

Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug‐resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social–emotional skill development are limited.
Ingrid E. Scheffer, M. Scott Perry, Joseph Sullivan, Susana Boronat, James Wheless, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +26 more
wiley   +1 more source

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, EarlyView.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source

3D Screen Printing Offers Unprecedented Anticounterfeiting Strategies for Oral Solid Dosage Forms Feasible for Large Scale Production

Pharmaceutics
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide.
Nicolle Schwarz, Marcel Enke, Franka V. Gruschwitz, Daniela Winkler, Susanne Franzmann, Lisa Jescheck, Felix Hanf, Achim Schneeberger   +7 more
doaj   +1 more source

Flexible organic room‐temperature phosphorescent materials

FlexMat, EarlyView.
This review highlights recent advances in flexible organic room‐temperature phosphorescent (RTP) materials, covering both organic crystal and polymer systems. It discusses strategies to overcome the inherent rigidity and enhance the mechanical flexibility of organic RTP materials, aiming to enable their practical applications in anti‐counterfeiting ...
Bolun Zhang, Xiaokang Shao, Wenjie Yin, Jiahui Xu, Beishen Wu, Zhongfu An, Huifang Shi   +6 more
wiley   +1 more source

Counterfeiting of drugs in Brazil.

Revista de saude publica, 2012
OBJETIVO: Identificar los principales medicamentos falsificados incautados por la Policía Federal Brasileña y los estados donde hubo incautación. MÉTODOS: Estudio retrospectivo descriptivo de los laudos periciales elaborados por Peritos Criminales de la Policía Federal brasileña sobre medicamentos falsos entre enero de 2007 y septiembre de 2010 ...
Ames, Joseane, Souza, Daniele Zago
openaire   +2 more sources

Sustainable Work and Employment in Social Care: New Challenges, New Priorities

Human Resource Management, EarlyView.
ABSTRACT Human Resource Management (HRM) research focused on social care is sparse. This gap is surprising given the scale of the social care workforce in many countries, its vital role in meeting the increasingly complex needs of vulnerable community groups, and the persistent challenges in recruiting and retaining staff.
Ian Kessler, Aoife M. McDermott, Lander Vermeerbergen, Valeria Pulignano, Brian Harney   +4 more
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

(Re)humanizing Blackness: Integrating BlackCrit in the Mental Health Counseling of Black Clients

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT Does Black mental health matter? Historically, mental illness in the Black community has been inadequately addressed. Yet Black Americans experience more severe psychological distress than other races, and they are also more likely to experience poor outcomes in counseling.
Demetrius Cofield
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

From Data to Decisions: How Machine Learning and Generative Artificial Intelligence Are Redefining Precision Medicine in Kidney Transplantation

Organ Medicine, EarlyView.
This review evaluates how machine learning, multimodal integration, and generative AI optimize kidney transplant outcomes. These tools enable superior prediction and personalized therapy but face hurdles in data volume, generalizability, and ethics. Future clinical adoption depends on continued innovation and multidisciplinary collaboration to overcome
Maoxin Liao, Cheng Yang
wiley   +1 more source