Results 61 to 70 of about 1,041,860 (274)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

The plague of unexpected drug recalls and the pandemic of falsified medications in cardiovascular medicine as a threat to patient safety and global public health: A brief review

Cardiology Journal, 2022
Valsartan, losartan, and irbesartan, are widely used in the treatment strategies of cardiovascular medicine diseases, including hypertension and heart failure.
Damian Świeczkowski, Szymon Zdanowski, Piotr Merks, Łukasz Szarpak, Régis Vaillancourt, Milosz J. Jaguszewski   +5 more
doaj   +1 more source

Predicting Single‐Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Advanced Science, EarlyView.
Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang, Ziqi Liu, Zhengqian Zhang, Yikun Cao, Junjun Ren, Peng Cheng, Jingjing Tian, Lingyun Xie, Xin Lu, Zhanwei Du, Yongzhuang Liu   +10 more
wiley   +1 more source

Quality of antimalarial drugs and antibiotics in Papua New Guinea : a survey of the health facility supply chain [PDF]

, 2014
Poor-quality life-saving medicines are a major public health threat, particularly in settings with a weak regulatory environment. Insufficient amounts of active pharmaceutical ingredients (API) endanger patient safety and may contribute to the ...
Betuela Inoni, Davis, T., Page-Sharp Madhu, Betuela, I., Page-Sharp, Madhu, Bala, Nancy, Bala Nancy, Manuel W Hetzel, Timothy M E Davis, Evelyn K Lavu, Pulford Justin, Lavu, Evelyn K., Nancy Bala, Nancy Bala (563875), Hetzel Manuel W., Davis Timothy M. E., Madhu Page-Sharp (563874), Evelyn K. Lavu (563877), Davis, Timothy M. E., Lavu Evelyn K., Justin Pulford, Lavu, E., Bala, N., Pulford, J., Madhu Page-Sharp, Betuela, Inoni, Inoni Betuela, Hetzel, M., Hetzel, Manuel W., Pulford, Justin, Justin Pulford (563876), Inoni Betuela (67110), Timothy M. E. Davis (112260), Manuel W. Hetzel (563873)   +33 more
core   +2 more sources

Real‐Time Multicolor Fluorescence Microscopy via Cross‐Channel Acquisition and Deep‐Learning‐Based Inference

Advanced Intelligent Discovery, EarlyView.
Sequential multicolor fluorescence imaging in dynamic microsystems is constrained by acquisition speed and excitation dose. This study introduces a real‐time framework to reconstruct spectrally separated channels from reduced cross‐channel acquisitions (frames containing mixed spectral contributions).
Juan J. Huaroto, Yuxin Jin, Nicholas Roy, Sarthak Misra   +3 more
wiley   +1 more source

The rise of counterfeit medication: an emerging threat?

Journal of the Pakistan Medical Association
Madam, The definition of health is far more complex than initially imagined. As per the World Health Organisation (WHO), the “health” is defined as complete physical, mental, and social well-being instead of simply the absence of any disease.1 In the ...
Muhammad Omar Larik
doaj   +1 more source

Counterfeit drugs in India: significance and impact on pharmacovigilance [PDF]

, 2017
Counterfeit drugs have emerged as a major global problem. This issue has been brought to the centre of the Indian media due to the death of 15 women attending a sterilization camp in Chhattisgarh.
Sattigeri, Bhagya M., Patel, Nirav N., Shah, Nehal A., Desai, Haresh A.   +3 more
core   +1 more source

Looking back on childhood experiences of homelessness: Stories of ongoing residential instability and resilience

American Journal of Community Psychology, EarlyView.
Abstract Families' experience of homelessness is typically examined from the perspective of parents during or shortly after a shelter stay. Parents complain about rules, surveillance, crowding, and challenges to parenting in both homeless shelters and in doubling up with other households (sharing the others' homes), and relief when they attain their ...
Marybeth Shinn, Emma J. Sacks, Kayla Fike   +2 more
wiley   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

Substandard, Spurious, Falsely-Labelled, Falsified and Counterfeit (SSFFC) Drugs: Time to Take a Bitter Pill [PDF]

Journal of Krishna Institute of Medical Sciences University, 2016
Substandard, Spurious, Falsely-Labelled, Falsified and Counterfeit (SSFFC) drugs are an emerging public health concern in India. With one of the huge pharmaceutical sectors in the world, India has a varied prevalence of SSSFC drugs ranging from 0.04% to ...
Geetha Mani, Raja Danasekaran, Kalaivani Annadurai   +2 more
doaj