Results 81 to 90 of about 1,041,860 (274)

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

DEVELOPMENT OF QUANTITATIVE HPTLC-DENSITOMETRY METHODS FOLLOWING A MODEL APPROACH FOR TRANSFER OF TLC SCREENING METHODS FOR PHARMACEUTICAL PRODUCTS OF METFORMIN HCL, POTASSIUM CLAVULANATE, CAFFEINE, FLUOXETINE HCL, AND GABAPENTIN

Studia Universitatis Babes-Bolyai Chemia, 2017
Transfer of thin-layer chromatography Global Pharma Health Fund Minilab kit protocols for detecting counterfeit drugs in pharmaceutical products in the field to quantitative high-performance TLC (HPTLC)-densitometry methods was carried out for potassium
Kaitlin NGUYEN, Danhui ZHANG, Joseph SHERMA   +2 more
doaj   +1 more source

Diffusion of counterfeit medical products in a developing country: Empirical evidence for Suriname [PDF]

Based on detailed shipping figures of Suriname’s main harbour in Paramaribo, we estimate the total shipments (in kilograms) of original and counterfeit medical products for 1996-2008 across five product categories. Using various time series techniques,
Franses, Ph.H.B.F., Lede, M.
core  

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, EarlyView.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

Quality of antidiabetic medicines in 13 sub-Saharan African countries: a cross-sectional surveyResearch in context

EClinicalMedicine
Summary: Background: The burden of diabetes is rising dramatically in low- and middle-income countries. The menace of substandard and falsified drugs constitutes a major hazard that compromises healthcare.
Marie Antignac, Roland N'Guetta, Philippe Henri Secretan, Bernard Do, Meo Stephane Ikama, Jean Bruno Mipinda, Ibrahim Ali Toure, Jean Laurent Takombe, Yves Lubenga, Mouhamadoul Mounir Dia, El Bou Isselmou Boukhary Ould, Maxwell Dalaba, Naby Moussa Balde, Amadou Kake, Ely Cheikh Ibrahima Sy, Pauline Cavagna, Marie Cécile Perier, Eugène Sobngwi, Pr Badara Cisse, Christian Boitard, J.P. Empana, I. Bara Diop, Maimouna Ndour Mbaye, Xavier Jouven   +23 more
doaj   +1 more source

Identification of Counterfeit Drugs by Community Pharmacists in Lagos State [PDF]

, 2007
Purpose: The problem of fake and counterfeit drugs is real and constitutes a major threat to the health and safety of the Nigerian population. A descriptive study was carried out to assess the methods of identification of counterfeit drugs by community ...
Osemwenkha, S, Eke, E U, Odili, V U, Okeri, H A   +3 more
core   +1 more source

Digital Technologies for Transparent and Sustainable Supply Chain Management: A Resource Orchestration‐Based View in the Textile Industry

Business Strategy and the Environment, EarlyView.
ABSTRACT Implementing digital technologies is touted as the next big step for the firms aiming to improve sustainability in their supply chains. These technologies are often credited with the potential to improve transparency and achieve sustainability.
Amna Farrukh, Aqeel Ahmed, Sadaat Yawar
wiley   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Experiences of Prisoners Living With Mental Health Conditions and Seeking or Receiving Mental Health Support in Prisons: An Integrative Review

Criminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background Prisoners experience poor mental health and well‐being in prison, including severe mental illnesses. However, access to mental health support and treatment in prison is limited. We conducted an integrative review to synthesise prisoners' experiences of living with mental ill health and/or seeking or receiving mental health support ...
Anne Kairu, Judith Dyson, Damian Breen, James Skinner, Manuela Jarrett, Joanne Brooke   +5 more
wiley   +1 more source