Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Physical aspects of electro osmotically interactive Cilia propulsion on symmetric plus asymmetric conduit flow of couple stress fluid with thermal radiation and heat transfer. [PDF]
Sci Rep, 2023 Akbar NS, Muhammad T.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
SURFACE ROUGHNESS EFFECTS ON SQUEEZE FILM BEHAVIOR IN POROUS TRANSVERSELY TRIANGULAR PLATES WITH COUPLE STRESS FLUID [PDF]
, 2020 The effect of surface roughness on squeeze film behavior between two transversely triangular plates with couple stress lubricant is analyzed when the upper plate has porous facing which approaches the lower plate with uniform velocity.
Santhana Krishnan, Sundarammal Kesavan
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Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct. [PDF]
Sci Prog, 2021 Akram S, Saleem N, Umair MY, Munawar S.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Analysis of newly developed fractal-fractional derivative with power law kernel for MHD couple stress fluid in channel embedded in a porous medium. [PDF]
Sci Rep, 2021 Arif M +4 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Mixed convection flow of couple stress fluid between vertical parallel plates with radiation and chemical reaction effects [PDF]
, 2014 Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.This paper studies the effects of thermal radiation and chemical reaction on two dimensional incompressible couple stress ...
Srinivasacharya, D., Kaladhar, K.
core
Comparative study of generalized couette flow of couple stress fluid using optimal homotopy asymptotic method and new iterative method. [PDF]
Sci Rep, 2021 Farooq M +5 more
europepmc +1 more source