Results 71 to 80 of about 226,083 (299)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Solitary vortex couples in viscoelastic Couette flow
, 1996 We report experimental observation of a localized structure, which is of a new type for dissipative systems. It appears as a solitary vortex couple ("diwhirl") in Couette flow with highly elastic polymer solutions.
A. C. Newell +13 more
core +1 more source
Effect of induced magnetic field on peristaltic flow of a micropolar fluid in an asymmetric channel [PDF]
, 2010 Of concern in this paper is an investigation of peristaltic transport of a physiological fluid in an asymmetric channel under long wave length and low-Reynolds number assumptions. The flow is assumed to be incompressible, viscous, electrically conducting
Ng, E. Y. K., Roy, M., Shit, G. C.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Aspects of hot Galilean field theory [PDF]
, 2014 We reconsider general aspects of Galilean-invariant thermal field theory. Using the proposal of our companion paper, we recast non-relativistic hydrodynamics in a manifestly covariant way and couple it to a background spacetime.
Jensen, Kristan
core +1 more source
Couple stress fluids in porous circular squeeze films
Applied Mathematical Sciences, 2015 The squeeze film flow characteristics of a couple stress fluid between porous circular disks is investigated. The modified Reynold’s equation is derived using Stokes microcontinuum theory and is solved analytically. The expressions for the squeeze film pressure and the squeeze film force are obtained in terms of Fourier-Bessel series. Numerical results
P. Vimala, G. Sumathi
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Results in Physics, 2018 The intention here is to investigate the effects of wall couple stress with energy and concentration transfer in magnetohydrodynamic (MHD) flow of a micropolar fluid embedded in a porous medium.
Asma Khalid +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source