Results 101 to 110 of about 8,192,067 (257)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The effect of couple-stresses on the stress concentration around a moving crack
International Journal of Mathematics and Mathematical Sciences, 1981 The problem of a uniformly propagating finite crack in an infinite medium is solved within the linearized couple-stress theory. The self-equilibrated system of pressure is applied to the crack surfaces.
S. Itou
doaj +1 more source
A Size-Dependent Finite Element Method for the 3D Free Vibration Analysis of Functionally Graded Graphene Platelets-Reinforced Composite Cylindrical Microshells Based on the Consistent Couple Stress Theory. [PDF]
Materials (Basel), 2023 Wu CP, Tan TF, Hsu HT.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Ferrofluid Based Squeeze Film Lubrication between Rough Stepped Plates with Couple Stress Effect
Journal of Applied Fluid Mechanics, 2018 This investigation purposes to study the magnetic fluid based squeeze film behavior on transversely rough stepped plates with the influence of couple stress.
Y. D. Vashi, R. M. Patel, G. M. Deheri
doaj
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Nonlinear Dynamical Analysis for a Plain Bearing
Advances in Mechanical Engineering, 2014 This paper investigates the nonlinear dynamic behavior for a plain classic bearing (fluid bearing) lubricated by a non-Newtonian fluid of a turbo machine rotating with high speed; this type of fluid contains additives viscosity (couple-stress fluid film).
Ali Belhamra +3 more
doaj +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source