Results 111 to 120 of about 5,402,366 (275)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Flexible and rigorous numerical modelling of multiphysics processes in fractured porous media using PorePy

Results in Applied Mathematics
Multiphysics processes in fractured porous media is a research field of importance for several subsurface applications and has received considerable attention over the last decade.
Ivar Stefansson, Jhabriel Varela, Eirik Keilegavlen, Inga Berre   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Determination of $$|V_{\textrm{cb}}|$$ | V cb | using Bayesian analysis of the $$B \rightarrow D^{*}\ell {\bar{\nu }}_\ell $$ B → D ∗ ℓ ν ¯ ℓ semileptonic decay width with four-loop QCD corrections

European Physical Journal C: Particles and Fields
The Cabibbo–Kobayashi–Maskawa matrix element $$|V_{\textrm{cb}}|$$ | V cb | is an important Standard Model parameter, whose value can be determined by using the semi-leptonic decay $$B\rightarrow D^{*}\ell {\bar{\nu }}_\ell $$ B → D ∗ ℓ ν ¯ ℓ .
Wang Li, Xing-Gang Wu, Hua Zhou, Xu-Chang Zheng   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Static spherical vacuum solution to bumblebee gravity with time-like VEVs

European Physical Journal C: Particles and Fields
The static spherical vacuum solution in a bumblebee gravity model where the bumblebee field $$B_\mu $$ B μ has a one-component time-like vacuum expectation value $$b_\mu $$ b μ is studied.
Hao Li, Jie Zhu
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Two-dimensional phase diagram of the charge density wave in doped CsV3Sb5

npj Quantum Materials
Kagome superconductors AV3Sb5 (A = K, Rb and Cs) have attracted much recent attention due to the coexistence of multiple exotic orders. Among them, the charge density wave (CDW) order has been shown to host various unconventional behaviors.
Linwei Huai, Hongyu Li, Yulei Han, Yang Luo, Shuting Peng, Zhiyuan Wei, Jianchang Shen, Bingqian Wang, Yu Miao, Xiupeng Sun, Zhipeng Ou, Bo Liu, Xiaoxiao Yu, Ziji Xiang, Min-Quan Kuang, Zhenhua Qiao, Xianhui Chen, Junfeng He   +17 more
doaj   +1 more source

Reanalysis of the top-quark pair production via the e+e− annihilation near the threshold region up to N3LO QCD corrections

Physics Letters B
In this paper, we present an improved analysis of the top-quark pair production via the process e+e−→γ⁎→tt¯ near the threshold region up to next-to-next-to-next-to-leading order (N3LO) QCD corrections.
Jiang Yan, Xing-Gang Wu, Zhi-Fei Wu, Jing-Hao Shan, Hua Zhou   +4 more
doaj   +1 more source