Results 111 to 120 of about 5,400,307 (274)

Flexible and rigorous numerical modelling of multiphysics processes in fractured porous media using PorePy

Results in Applied Mathematics
Multiphysics processes in fractured porous media is a research field of importance for several subsurface applications and has received considerable attention over the last decade.
Ivar Stefansson, Jhabriel Varela, Eirik Keilegavlen, Inga Berre   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Determination of $$|V_{\textrm{cb}}|$$ | V cb | using Bayesian analysis of the $$B \rightarrow D^{*}\ell {\bar{\nu }}_\ell $$ B → D ∗ ℓ ν ¯ ℓ semileptonic decay width with four-loop QCD corrections

European Physical Journal C: Particles and Fields
The Cabibbo–Kobayashi–Maskawa matrix element $$|V_{\textrm{cb}}|$$ | V cb | is an important Standard Model parameter, whose value can be determined by using the semi-leptonic decay $$B\rightarrow D^{*}\ell {\bar{\nu }}_\ell $$ B → D ∗ ℓ ν ¯ ℓ .
Wang Li, Xing-Gang Wu, Hua Zhou, Xu-Chang Zheng   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Static spherical vacuum solution to bumblebee gravity with time-like VEVs

European Physical Journal C: Particles and Fields
The static spherical vacuum solution in a bumblebee gravity model where the bumblebee field $$B_\mu $$ B μ has a one-component time-like vacuum expectation value $$b_\mu $$ b μ is studied.
Hao Li, Jie Zhu
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Reanalysis of the top-quark pair production via the e+e− annihilation near the threshold region up to N3LO QCD corrections

Physics Letters B
In this paper, we present an improved analysis of the top-quark pair production via the process e+e−→γ⁎→tt¯ near the threshold region up to next-to-next-to-next-to-leading order (N3LO) QCD corrections.
Jiang Yan, Xing-Gang Wu, Zhi-Fei Wu, Jing-Hao Shan, Hua Zhou   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source