Results 91 to 100 of about 682,008 (293)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A Generalization of Fixed-Point Theorems for Mappings with a Contractive Iterate

open access: yesMathematics
In this paper, a generalization of fixed-point mappings with an iterate at a point in complete metric spaces is shown, using the notions of T-closed sets and i-P-regularity/d-P-regularity, proving conditions for the existence and uniqueness of the fixed ...
Valentin Georgiev, Boyan Zlatanov
doaj   +1 more source

Positive solutions of fractional integral equations by the technique of measure of noncompactness

open access: yesJournal of Inequalities and Applications, 2017
In the present study, we work on the problem of the existence of positive solutions of fractional integral equations by means of measures of noncompactness in association with Darbo’s fixed point theorem. To achieve the goal, we first establish new fixed
Hemant Kumar Nashine   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Coupled fixed point theorems in C*-algebra-valued b-metric spaces

open access: yes, 2017
In this paper, we give some coupled fixed point results in the framework of C∗algebra-valued b-metric spaces and in particular in the setting of C∗ algebra-valued metric spaces.
S. Radenović   +3 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Common Coupled Fixed Point Theorems of Single-Valued Mapping for c-Distance in Cone Metric Spaces

open access: yesAbstract and Applied Analysis, 2012
The existence and uniqueness of the common coupled fixed point in cone metric spaces have been studied by considering different types of contractive conditions.
Zaid Mohammed Fadail   +1 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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