Results 91 to 100 of about 7,223,590 (284)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Measures of weak noncompactness and fixed point theory in banach algebras satisfying condition (P)

, 2017
The aim of this paper is to prove some new fixed point theorems in a nonempty closed convex subset of a Banach algebra satisfying a sequential condition (P) in a weak topology setting.peer ...
O’Regan, Donal, Ben Amar, Afif
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Some New Coupled Coincidence Point and Coupled Fixed Point Results in Partially Ordered Metric-Like Spaces and an Application

Journal of Function Spaces, 2018
Some new coupled coincidence point and coupled fixed point theorems are established in partially ordered metric-like spaces, which generalize many results in corresponding literatures. An example is given to support our main results.
Min Liang, Chuanxi Zhu, Zhaoqi Wu, Chunfang Chen   +3 more
doaj   +1 more source

New Results on Fixed Points and Coupled Fixed Points for α-Admissible Condensing Operators

Axioms
This paper introduces a novel class of condensing mappings through the concept of α-admissibility. We prove several extensions of Darbo’s fixed point theorem within this framework, including a generalized contractive condition and a coupled fixed point result. Our main results extend the classical condensing condition to a flexible inequality involving
Taoufik Moulahi, Najmeddine Attia
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Common fixed point and common coupled fixed point theorems for weakly monotone mappings

Boletim da Sociedade Paranaense de Matemática
In this paper we have established two common fixed point theorems which are variants of the fixed point theorem of Boyd and Wong [On nonlinear contractions, Proc. Amer. Math. Soc. 20(1969), 458-464]. By applying the newly established fixed point theorems two common coupled fixed point theorems have been proved for a pair of weakly increasing mappings ...
E. Prajisha, P. Shaini
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nonlinear Contraction-Based Coupled Fixed Point Theorems in Partial b-Metric Spaces with Applications

Applied Mathematics on Science and Engineering
In (Mediterr. J. Math. 11, 703–711, 2014), Shukla introduced the concept of partial b-metric spaces as a generalization of partial metric and b-metric spaces.
Muhammed Raji, Yahaya Jibrin Danjuma, Michael Bamidele David, Isaac Adaji, Aminu Ibrahim   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source