Results 71 to 80 of about 1,058,541 (295)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modeling the influence of environmental factors on human respiratory irritation from natural exposures to Karenia brevis aerosols [PDF]

, 2015
Presented at CERF 2015: Grand Challenges in Coastal & Estuarine Science, Portland, Oregon, November 8 - 12, 2015 and at the Eighth Symposium on Harmful Algae in the U.S., Long Beach, California, November 15 – 19, 2015.The Coupled Natural and Human ...
Hitchcock, Gary, Hoagland, Porter, Kirkpatrick, Barbara, Kirkpatrick, Gary   +3 more
core  

Research on Coupled Human and Natural Systems (CHANS): Approach, Challenges, and Strategies [PDF]

The Bulletin of the Ecological Society of America, 2011
William J. McConnell, James D. A. Millington, Nicholas J. Reo, Marina Alberti, Heidi Asbjornsen, Lawrence A. Baker, Nicholas Brozov, Laurie E. Drinkwater, Scott A. Drzyzga, Jose, Fragoso, Daniel S. Holland, Claire A. Jantz, Timothy Kohler, Herbert D. G. Maschner, Michael Monticino, Guillermo Podesta, Robert Gilmore Pontius, Jr., Charles L.
McConnell, William, Millington, James, Reo, Nicholas, Alberti, Marina, Asbjornsen, Heidi, Baker, Lawrence, Brozovic, Nicholas, Drinkwater, Laurie, Drzyzga, Scott, Fragoso, José, Holland, Daniel, Jantz, Claire, Kohler, Timothy, Maschner, Herbert, Monticino, Michael, Podestá, Guillermo, Pontius, Robert, Redman, Charles, Sailor, David, Urquhart, Gerald, Liu, Jianguo   +20 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Self-Organization of Speech Sounds [PDF]

, 2005
The speech code is a vehicle of language: it defines a set of forms used by a community to carry information. Such a code is necessary to support the linguistic interactions that allow humans to communicate. How then may a speech code be formed prior to
Oudeyer, Pierre-Yves
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

State-level variation drives wolf management in the northwestern United States

Environmental Research: Ecology
Recovered and recovering carnivore populations in Europe and North America can pose risks to some human livelihoods like livestock ranching. These risks can motivate wildlife managers to lethally remove carnivores—decisions that are often controversial ...
Leandra Merz, Nicolas T Bergmann, Casey L Brown, Jeff Vance Martin, Chloe B Wardropper, Jeremy T Bruskotter, Neil H Carter   +6 more
doaj   +1 more source

Reflooding the coupled human and natural system of the Waza-Logone Floodplain, Cameroon

Frontiers in Conservation Science
The rewilding framework is used to guide the restoration of ecological processes in natural systems, but the framework can also be used in the restoration of social and ecological processes in coupled human and natural systems.
Mark Moritz, Chelsea E. Hunter, Paul Scholte   +2 more
doaj   +1 more source