Results 101 to 110 of about 4,152,141 (291)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Comparison of various approaches to numerical simulation of ship resistance and propulsion

, 2014
The operation of a marine propeller dominates the flow interaction effects and alters the resistance on an upstream hull and the forces on a downstream rudder.
Winden, B., Lidtke, Artur Konrad, Hudson, D.A., Badoe, C., Turnock, S.R., Phillips, A.B., Lidtke, A.K.   +6 more
core   +1 more source

Coupled Simulation Study on the High-Pressure Air Expulsion from Submarine Ballast Tanks and Emergency Surfacing Dynamics

Journal of Marine Science and Engineering
Emergency surfacing acts as the final line of defense in preserving the operational viability of submarines, playing a crucial role in their safety. To investigate the dynamic characteristics of submarine emergency surfacing, utilizing whole moving mesh ...
Jiabao Chen, Likun Peng, Bangjun Lv, Wei Pan, Yong Wang   +4 more
doaj   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Impact of Non-Gaussian Winds on Blade Loading and Fatigue of Floating Offshore Wind Turbines

Journal of Marine Science and Engineering
This study introduces a novel methodology for estimating loading and fatigue damage in the blades of wind turbines, emphasizing non-Gaussian wind conditions’ impact.
Shu Dai, Bert Sweetman, Shanran Tang
doaj   +1 more source

A Fully Coupled Simulation of Planar Deposition Flow and Fiber Orientation in Polymer Composites Additive Manufacturing. [PDF]

Materials (Basel), 2021
Wang Z, Smith DE.
europepmc   +1 more source

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source

Numerical modelling of non-linear coupled thermo-electric problems: A comparative study

, 2009
Purpose – The purpose of this paper is to access performance of existing computational techniques to model strongly non-linear coupled thermo-electric problems.
Golosnoy, I.O., Sykulski, J.K.
core   +1 more source

dynoGP: Deep Gaussian Processes for Dynamic System Identification

International Journal of Adaptive Control and Signal Processing, EarlyView.
This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli, Marco Forgione, Dario Piga, Marco Zaffalon   +3 more
wiley   +1 more source

Finite Element Analysis of Hybrid Piezo- and Pyroelectric Energy Harvesting

Applied Sciences
Pyropiezoelectric energy harvesting has the potential to utilize both environmental vibrations and time-dependent temperature changes to increase the amount of energy harvested compared to harvesting from only one of the two sources.
Michael Stefan Schwarz, Julia Mergheim
doaj   +1 more source