Results 101 to 110 of about 1,566,452 (319)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Extension-twist coupled laminates for aero-elastic compliant blade design [PDF]
, 2012 A definite list of laminate configurations with extension-twisting (and shearing-bending) coupling is derived for up to 21 plies of identical thickness.
Christopher York, York, C.B.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Compound laser modes of mutually delay-coupled lasers : bifurcation analysis of the locking region
, 2004 A system of two mutually delay-coupled semiconductor lasers with a small delay of 170 ps in the coupling is studied. Apart from a possible difference in their optical frequencies, we consider two identical lasers.
Lenstra, D, Erzgraber, H, Krauskopf, B
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A coupled MBS-FEM approach for computing the dynamic overloads in thin web gears
, 2015 In aerospace gearboxes, very thin gears are used in order to reduce the weight of the system. The low stiff of such gears introduces additional natural frequencies in the working range of the gearbox, determining noise and sometimes fatigue failures ...
ROSSO, CARLO +2 more
core
EnergiesGravity-assisted separation heat pipes (GSHPs) are extensively utilized in telecommunications base stations and data centers. To ensure year-round cooling, integrating GSHPs directly with a vapor compression refrigeration system is a viable solution.
Yiming Rongyang +5 more
doaj +1 more source
Advances in Difference Equations, 2017 This article is concerned to the investigation of extremal solutions for a system of fractional order differential equations with coupled integral boundary value problem.
Yongjin Li, Kamal Shah, Rahmat Ali Khan
doaj +1 more source