Results 81 to 90 of about 189,032 (295)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Working With Parts Of the Self Within the EFT Framework
Психология и Психотерапия СемьиEmotionally Focused Therapy (EFT) and the Internal Family Systems (IFS) model are independent and theoretically complete approaches. The former works with the dyad through the lens of attachment theory, while the latter focuses on the internal system of ...
Oksana Trushina
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Impact of approaches in improving male partner involvement in the prevention of mother-to-child transmission (PMTCT) of HIV on the uptake of PMTCT services in sub-Saharan Africa: a protocol of a systematic review and meta-analysis [PDF]
, 2016 Introduction: Several studies have reported approaches used in improving the delivery of prevention of mother-to-child transmission (PMTCT) of HIV services through the involvement of male partners, but evidence from a systematic review is limited. We aim
Johnman, Cathy +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Comparison Effectiveness Wisdom-Focused Couple Therapy with Emotional-Focused Couple Therapy on Sense of Coherence in Couples with Marital Conflicts [PDF]
روانشناسی بالینی و شخصیتIntroduction: This research aims to compare the effectiveness of wisdom-focused couple therapy with emotion-focused couple therapy in enhancing the sense of coherence among couples experiencing marital conflicts.Method: This study employed a semi ...
Nazanin Khoshbakht +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
مجله علوم روانشناختی, 2019 Background: Family and couples may have difficulties in various functions and variables, including the basic psychological needs. Research has shown the effectiveness of structural family therapy on various variables, but the basic psychological needs of
Nazita Akhlaghi nosheri +3 more
doaj
"Risking the Kids" versus "Double the Love": Couple-counsellors in Conversation on LGB Parenting. [PDF]
, 2007 The literature on lesbian, gay and bisexual (LGB) affirmative psychotherapy suggests that heterosexist and homophobic discourses persist in the accounts of counsellors and therapists (Milton, Coyle & Legg, 2005) and that these may particularly cohere ...
Barker, M., Evans, Margaret
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source