Results 101 to 110 of about 1,716,980 (301)

Coupling Coordination Analysis of China's Provincial Water-Energy-Food Nexus

, 2022
International audienceWater, energy and food are three essential resources for the socio-economic system, and they are interlinked. The coordination of their internal relations is worth studying.
Qi, Yingying, Farnoosh, Arash, Lin, Lu, Liu, Hui   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cahier pédagogique de la coordination provinciale de la philosophie

, 1973
Publ. comme le vol. 2, no.
Québec (Province). Coordination provinciale de la philosophie
core   +1 more source

The coupling coordination relationship and promotion path of green economic efficiency and urban land development intensity: based on the case study of 283 prefecture-level cities

Frontiers in Sustainable Food Systems
The coordination and interaction of green economy efficiency (GEE) and urban land development intensity (ULDI) constitute a critical pathway toward achieving sustainable urban development.
Jiao Hou, Jiao Hou, Xupeng Zhang, Zhenhui Qi, Zhu Mei, Xinhai Lu, Mengna Li, Xinxue Cheng, ManJing Chen, Xiangyu Fan, Xiangyu Fan   +10 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Quantifying the Synergy Between Industrial Structure Optimization, Ecological Environment Management, and Socio-Economic Development

Buildings
In the context of the new developmental philosophy, this study aimed to address the bottleneck of regional sustainable development; it constructs a three-system evaluation indicator system for Industrial Structure Optimization (ISO), Ecological ...
Zexi Xue, Zhouyun Chen, Qun Lin, Ansheng Huang   +3 more
doaj   +1 more source