Results 91 to 100 of about 110,100 (307)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Endocannabinoid Release Modulates Electrical Coupling between CCK Cells Connected via Chemical and Electrical Synapses in CA1.

, 2011
Electrical coupling between some subclasses of interneurons is thought to promote coordinated firing that generates rhythmic synchronous activity in cortical regions.
Ali eAfia, Jonathan eIball, Afia B. Ali, Jonathan Iball, Iball, J, Ali, AB   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Locational-based Coupling of Electricity Markets: Benefits from Coordinating Unit Commitment and Balancing Markets

, 2011
We formulate a series of stochastic models for committing and dispatching electric generators subject to transmission limits. The models are used to estimate the benefits of electricity locational marginal pricing (LMP) that arise from better ...
Benjamin Hobbs, van der Weijde, A.H., Adriaan Weijde, Weijde, A.H. van der, Hobbs, B.F., Benjamin F. Hobbs, Adriaan Hendrik van der Weijde   +6 more
core   +1 more source

Classification of coupling coordination degree.

, 2023
In 2014, the Chinese government unveiled the New Urbanization Plan and Document No. 46, which profoundly influenced the development trajectory of the regional economy and sports industry.
Yang Zhang (30734), Lide Su (11801639), AGUDAMU (17087358), Yuqian Liu (1413763)   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The coupling coordination relationship and promotion path of green economic efficiency and urban land development intensity: based on the case study of 283 prefecture-level cities

Frontiers in Sustainable Food Systems
The coordination and interaction of green economy efficiency (GEE) and urban land development intensity (ULDI) constitute a critical pathway toward achieving sustainable urban development.
Jiao Hou, Jiao Hou, Xupeng Zhang, Zhenhui Qi, Zhu Mei, Xinhai Lu, Mengna Li, Xinxue Cheng, ManJing Chen, Xiangyu Fan, Xiangyu Fan   +10 more
doaj   +1 more source

THE ROLE OF PREVIOUS ANTERIOR CRUCIATE LIGAMENT INJURY ON THE VARIABILITY OF JOINT KINEMATICS AND COORDINATION DURING A MATCH SPECIFIC LAND-CUT TASK

, 2012
This study compared the movement and coordination variability of the previously injured leg of ACL injured subjects (ACLr, n=9), against their non-injured leg and a control (nACL, n=9) leg.
Harrison, Andrew, Breen, Sarah, Kenny, Ian, Breen, S, Kenny, IC, Harrison, AJ   +5 more
core  

Rowing together: Interpersonal coordination dynamics with and without mechanical coupling [PDF]

, 2019
Although most research on interpersonal coordination focuses on perceptual forms of interaction, many interpersonal actions also involve interactions of mechanical nature.
Zaal, Frank T. J. M., Cuijpers, Laura S., Zaal, Frank T. J. M.; id_orcid, den Hartigh, Ruud J. R., Cuijpers, Laura S.; id_orcid, den Hartigh, Ruud J. R.; id_orcid, de Poel, Harjo J.   +6 more
core   +1 more source