Results 51 to 60 of about 42,412 (298)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Where is the pathway to sustainable urban development? Coupling coordination evaluation and configuration analysis between low-carbon development and eco-environment: A case study of the Yellow River Basin, China

Ecological Indicators, 2022
Coupling coordination is the core connotation of sustainable urban development. Few studies have considered the coupling coordination between low-carbon development and eco-environment (LC-EE) simultaneously for the key region, and ignored the ...
Lan Luo, Yanan Wang, Yangcheng Liu, Xiangwei Zhang, Xiaoli Fang   +4 more
doaj   +1 more source

Logistics and economic coupling coordination degree.

Logistics and economic coupling coordination degree.
Xue Du (495057), Bo Sun (177052), Enqiu He (17889301), Zhiyuan An (6472952)   +3 more
core   +2 more sources

Coupling degree and coordination degree of urban agricultural informatization and agricultural economic development in Shandong Province.

, 2022
Coupling degree and coordination degree of urban agricultural informatization and agricultural economic development in Shandong Province.
Zhe Zhao (157204), Yu Sun (18463), Mingquan Li (9225594)   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The coordinated impacts of agricultural insurance and digital financial inclusion on agricultural output: Evidence from China

Heliyon, 2023
The coordinated development of agricultural insurance and digital financial inclusion is crucial to agricultural production, previous research on the subject is unclear.
Chaofan An, Xiaoxia He, Lin Zhang
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Research on the coupling measurement of medical education and health resource allocation under the background of healthy China

BMC Medical Education
Objective To analyze the coupling and coordination level of medical education and health resource allocation in China, and to provide scientific basis for promoting the high-quality development of medical education and the efficient allocation of health ...
Chen Jieting, Zhu Yan, Song Zhilong, Li Siyuan, Wu Xiangwei   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source