Results 101 to 110 of about 215,407 (319)

The Coupling Coordination Degree of Marine Economy-Society-Ecology System in China

Haiyang Kaifa yu guanli, 2023
Judging the coordinated development trend of China's marine economy-society-ecology system has important strategic decision-making reference value for promoting the high-quality development of China's marine economy.
Fuzhu LI, Miaozhen JIA
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Emergent properties hidden in plane view: Strong electronic correlations at oxide interfaces

, 2014
Finding new collective electronic states in materials is one of the fundamental goals of condensed matter physics. Atomic-scale superlattices formed from transition metal oxides are a particularly appealing hunting ground for new physics.
Chakhalian, Jak, Freeland, John W., Millis, Andrew J., Panagopoulos, Christos, Rondinelli, James M.   +4 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Network Synchronization in a Noisy Environment with Time Delays: Fundamental Limits and Trade-Offs

, 2010
We study the effects of nonzero time delays in stochastic synchronization problems with linear couplings in an arbitrary network. Using the known exact threshold value from the theory of differential equations with delays, we provide the ...
Hunt, D., Korniss, G., Szymanski, B. K.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Network structure and dynamics of hydrogenated amorphous silicon

, 2007
In this paper we discuss the application of current it ab initio computer simulation techniques to hydrogenated amorphous silicon (a-Si:H). We begin by discussing thermal fluctuation in the number of coordination defects in the material, and its ...
Abtew, Abtew, Abtew, Abtew, Abtew, Abtew, Atta-Fynn, Atta-Fynn, Bazant, Biswas, Bobela, Branz, Cappelletti, Cobb, D.A. Drabold, Djordjevic, Drabold, Drabold, Drabold, F. Inam, Fedders, Fedders, Fedders, Feldman, Franz, Fritzsche, Herrero, Jackson, Kresse, Kwon, Lanzavecchia, Li, Nosé, Santos, Soler, Su, Su, T.A. Abtew, Tafen, Van de Walle, Van de Walle, Wooten, Y. Pan, Zhang, Ziman   +44 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Interplay between structure and magnetism in the low-dimensional spin system $K(C_8H_{16}O_4)_2CuCl_3{*}H_2O$

, 2017
Materials based on a crown ether complex together with magnetic ions, especially Cu(II), can be used to synthesize new low dimesional quantum spin systems. We have prepared the new crown ether complex Di-\mu-chloro-bis(12-crown-4)-aquqdichloro-copper(II)-
Assmus, Wolf, Bolte, Michael, Delley, Bernard, Krellner, Cornelius, Lang, Michael, Rüegg, Christian, Schefer, Jürg, van Well, Natalija, Wolf, Bernd   +8 more
core   +1 more source