Results 91 to 100 of about 299,628 (304)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Near-unity fueling light into a single plasmonic nanocavity

Nanophotonics
Plasmonic nanocavities have emerged as a powerful platform for extreme light confinement, enabling transformative applications in single-molecule Raman spectroscopy, ultra-sensitive sensing, strong light–matter interactions, etc.
Ye Haiming, Ge Junhao, Lu Zhengyi, Song Dudu, Ji Jiamin, Peng Zhaoyang, Zhang Shunping, Xu Hongxing   +7 more
doaj   +1 more source

Optimization of plasmon–plasmon coupling in photorefractive layered media [PDF]

, 2013
In this paper we study grating-induced plasmon–plasmon coupling in photorefractive layered media using a weakcoupling approximation. The method used is applicable to general layered structures that support both plasmonic and optical modes, such as ...
Daly, K.R., Abbott, S.B., Smith, D.C., D'Alessandro, G.D.   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Graphene-Loaded LiNbO₃ Directional Coupler: Characteristics and Potential Applications

Nanomaterials
This study explores the impact of graphene integration on lithium niobate (LiNbO3, LN) ridge waveguides and directional couplers, focusing on coupling efficiency, polarization-dependent light absorption, and temperature sensitivity.
Yifan Liu, Fei Lu, Hui Hu, Haoyang Du, Yan Liu, Yao Wei   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Design and Analysis of a High-Efficiency Dynamic Wireless Power Transfer System for In-Motion EV Charging

Applied Sciences
Dynamic wireless power transfer (DWPT) systems for in-motion electric vehicle (EV) charging often suffer from unstable power delivery due to spatial variations in magnetic coupling caused by vehicle misalignment.
Md Aurongjeb, Yumin Liu, Muhammad Ishfaq
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transmission Efficiency of a MEMS Laser Fuze for Safety and Arming

Micromachines
Owing to their superior performance in countering electromagnetic interference on the battlefield, laser fuzes have become a promising candidate for application in munition systems.
Kuang Fang, Shanglong Xu, Wenzhi Qin, Jiangnan Ran, Chao Chen, Peng Yang, Yalong Dai   +6 more
doaj   +1 more source