Results 101 to 110 of about 299,628 (304)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High-Efficiency Fiber Edge Coupling for Silicon Nitride Integrated Photonics

Micromachines
Photonic integrated circuits play a crucial role in almost every aspect of modern life, such as data storage, telecommunications, medical diagnostics, green energy, autonomous driving, agriculture, and high-performance computing.
Sergey S. Avdeev, Aleksandr S. Baburin, Evgeniy V. Sergeev, Alexei B. Kramarenko, Arseniy V. Belyaev, Danil V. Kushnev, Kirill A. Buzaverov, Ilya A. Stepanov, Vladimir V. Echeistov, Ales S. Loginov, Sergey V. Bukatin, Ali Sh. Amiraslanov, Evgeniy S. Lotkov, Dmitriy A. Baklykov, Ilya A. Rodionov   +14 more
doaj   +1 more source

Power Coupling Efficiency Enhancement in Multimode Step-Index Fiber Using Refractive and Diffractive Microlenses

International Journal of Optics, 2010
A novel study has been undertaken for the coupling efficiency enhancement on planar (refractive and diffractive) microlenses as coupling elements with various geometrical shapes in fibre optics communication. When the dispersion of the planar diffractive
S. Selvanandan, P. M. Anbarasan
doaj   +1 more source

High coupling efficiency adiabatic near-field transducer for HAMR

, 2018
The literature reports NFT with size below 1 micron are found to be thermo-mechanically unstable and low coupling efficiency. We demonstrate a 6 μm long adiabatic taper.
Chuan Zhong, Flanigan, Patrick, Hobbs, Richard, Richard Hobbs, Li, Jing, Frank Bello, Zhong, Chuan, Patrick Flanigan, Abadia, Nicolas, Donegan, John F., Atcheson, Gwenael, McCloskey, David, Zheng, Jian-Yao, Brian Jennings, David McCloskey, Jian-Yao Zheng, Jing Li, Bello, Frank, Jennings, Brian, Nicolás Abadía, Gwenael Atcheson, John F. Donegan   +21 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Reliability Study of Fiber Coupling Efficiency of 980 nm Semiconductor Laser

Photonics
In order to improve the stability of semiconductor laser fiber coupling efficiency, based on the coupling principle, the optimal parameters for semiconductor laser fiber coupling were simulated to be θ = 45°, r = 3.25 μm, and z = 5.65 μm.
Gang Liu, Shuhao Pang, Xin Zhang, Mingzhi Tang, Lei Liang, Rui Li, Rui Huang   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Coupling efficiency of the tapered coupler

Electronics Letters, 1975
Analytic solutions, in terms of parabolic cylinder functions, are presented for the mode amplitudes and power in a directional coupler having a constant coupling coefficient and propagation constants that vary linearly. The solutions lead to a remarkably simple expression for the coupling efficiency.
openaire   +1 more source