Results 111 to 120 of about 904,763 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Reliability Study of Fiber Coupling Efficiency of 980 nm Semiconductor Laser

Photonics
In order to improve the stability of semiconductor laser fiber coupling efficiency, based on the coupling principle, the optimal parameters for semiconductor laser fiber coupling were simulated to be θ = 45°, r = 3.25 μm, and z = 5.65 μm.
Gang Liu, Shuhao Pang, Xin Zhang, Mingzhi Tang, Lei Liang, Rui Li, Rui Huang   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Thermodynamic Bounds on Efficiency for Systems with Broken Time-reversal Symmetry

, 2011
We show that for systems with broken time-reversal symmetry the maximum efficiency and the efficiency at maximum power are both determined by two parameters: a "figure of merit" and an asymmetry parameter.
Giuliano Benenti, Giulio Casati, H. B. Callen, I. I. Novikov, J. Yvon, Keiji Saito, P. Chambadal, S. Carnot, S. Datta   +8 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Investigation of the power coupling of novel wavelength-selective couplers incorporating axially symmetric long-period fibre gratings

South African Journal of Science, 2011
Evanescent-field coupling was studied experimentally in novel optical-fibre-based wavelength-selective couplers, using axially symmetric long-period fibre grating (LPFG) structures.
Ronnie Kritzinger, Johan Meyer, Johan Burger   +2 more
doaj  

Study on the Influence of Atmospheric Light Intensity Scintillation Effect on Optical Fiber Coupling Efficiency

Photonics
Light intensity flicker is the most basic and important effect of turbulence. Fiber coupling efficiency is the primary parameter that ensures the system’s communication quality.
Xiaoying Ding, Xin Zhao
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Efficient fiber coupling of down-conversion photon pairs

, 2004
We develop and apply an effective analytic theory of a non-collinear, broadband type-I parametric down-conversion to study a coupling efficiency of the generated photon pairs into single mode optical fibers.
A. B. U’Ren, A. Yariv, D. N. Klyshko, D. N. Nikogosyan   +3 more
core   +1 more source