Results 101 to 110 of about 5,328,774 (332)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Neel to spin-Peierls transition in a quasi-1D Heisenberg model coupled to bond phonons

, 2013
The zero and finite temperature spin-Peierls transitions in a quasi-one-dimensional spin-1/2 Heisenberg model coupled to adiabatic bond phonons is investigated using the Stochastic Series Expansion (SSE) Quantum Monte Carlo (QMC) method.
Pillay, Jason Cornelius, Sengupta, Pinaki, Wierschem, Keola   +2 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Behaviour of Plate Anchorage in Plate-Reinforced Composite Coupling Beams

The Scientific World Journal, 2013
As a new alternative design, plate-reinforced composite (PRC) coupling beam achieves enhanced strength and ductility by embedding a vertical steel plate into a conventionally reinforced concrete (RC) coupling beam.
W. Y. Lam, Lingzhi Li, R. K. L. Su, H. J. Pam   +3 more
doaj   +1 more source

Vertical antiresonant reflecting optical waveguide coupler for three-dimensional optical interconnects: optimum design for large tolerance, high coupling efficiency, and short coupling length.

Applied Optics, 2000
A compact antiresonant-reflecting-optical-waveguide-(ARROW-) type vertical coupler for three-dimensional optical interconnects was demonstrated. The coupler consists of stacked ARROW's channeled by the stripe lateral confinement structure, and each ...
Sekimoto Takashi, Ikuta Shigenori, W. Pan, S. Chu, Y. Kokubun   +4 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Instabilities and Patterns in Coupled Reaction-Diffusion Layers

, 2012
We study instabilities and pattern formation in reaction-diffusion layers that are diffusively coupled. For two-layer systems of identical two-component reactions, we analyze the stability of homogeneous steady states by exploiting the block symmetric ...
Catlla, Anne J., McNamara, Amelia, Topaz, Chad M.   +2 more
core   +1 more source

Tilt-to-length coupling in LISA—uncertainty and biases

Classical and Quantum Gravity
Abstract The coupling of the angular jitter of the spacecraft and their sub-assemblies with the optical bench and the telescope into the interferometric length readout will be a major noise source in the LISA mission. We refer to this noise as tilt-to-length (TTL) coupling.
M-S Hartig, J Marmor, D George, S Paczkowski, J Sanjuan   +4 more
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Asymmetric Two-component Fermion Systems in Strong Coupling

, 2005
We study the phase structure of a dilute two-component Fermi system with attractive interactions as a function of the coupling and the polarization or number difference between the two components.
A. I. Larkin, A. L. Fetter, J. Carlson, Sanjay Reddy   +3 more
core   +1 more source