Results 81 to 90 of about 316,985 (297)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Interfaces and interfacial effects in glass reinforced thermoplastics - Keynote Presentation [PDF]
, 2007 Optimization of the fibre-matrix interphase region is critical to achieving the required performance level in thermoplastic matrix composites. Due to its initial location on the fibre surface, the sizing layer is an important component in the formation ...
Thomason, J.L.
core
The Transport Performance of Feedback Coupled Brownian Ratchets
MATEC Web of Conferences, 2017 The directed transport properties of feedback coupled Brownian ratchets under the effect of external periodic force and load force are investigated. The influence of the coupling strength on the transport properties of coupled system is discussed in ...
Fan LiMing +3 more
doaj +1 more source
New insights into the differences between the dual node approach and the common node approach for coupling surface–subsurface flow [PDF]
Hydrology and Earth System Sciences, 2017 The common node approach and the dual node approach are two widely applied approaches to coupling surface–subsurface flow. In this study both approaches are analyzed for cell-centered as well as vertex-centered finite difference schemes.
R. de Rooij
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Coherence Length of Cold Exciton Gases in Coupled Quantum Wells [PDF]
Physical Review Letters, 2006 5 pages, 3 ...
Yang, Sen +4 more
openaire +4 more sources
Experimental Demonstration of Reduced Tilt-to-length Coupling by Using Imaging Systems in Precision Interferometers [PDF]
, 2017 Angular misalignment of one of the interfering beams in laser interferometers can couple into the interferometric length measurement and is called tilt-to-length (TTL) coupling in the following.
Fernández, Barránco, G. +33 more
core +1 more source
The perfect waveguide coupler with universal impedance matching and transformation optics
NanophotonicsEfficient energy transfer is crucial in electromagnetic communication. Therefore, producing a waveguide coupler that achieves broadband, nonreflective transmission is a challenging task. With the advancement of silicon-based integrated photonic circuits,
Kim Myeongjin, Park Q-Han
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source