Results 61 to 70 of about 3,108,292 (291)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Study on properties of composites reinforced by heat treated glass fibres simulating thermal recycling conditions [PDF]

, 2013
In the present study, commercial chopped glass fibres were heat treated at 300°C, 450°C, 500°C and 600°C to imitate a composite thermal recycling process.
Thomason, James, Nagel, Ulf, Kao, Chih-Chuan   +2 more
core   +3 more sources

Unraveling the ultra-broadband beam splitter based on parallel coupled waveguides

JPhys Photonics
An ultra-broadband beam splitter is theoretically realized using a directional parallel-cascaded coupled-waveguide structure, which is designed and investigated with the effective medium method and finite-difference time-domain method. The 1 dB bandwidth
Sheng Hsiung Chang
doaj   +1 more source

Study of Baffle Boundary and System Parameters on Liquid-Solid Coupling Vibration of Rectangular Liquid-Storage Structure

Shock and Vibration, 2016
In order to study the vibration problem of liquid-solid coupling of rectangular liquid-storage structure with horizontal elastic baffle, ignoring the influence of surface gravity wave, two different velocity potential functions corresponding to the ...
Wei Jing, Xuansheng Cheng, Wei Shi, Jin Fan, Huan Feng   +4 more
doaj   +1 more source

Coupling iterated Kolmogorov diffusions [PDF]

, 2004
The Kolmogorov (1934) diffusion is the two-dimensional diffusion generated by real Brownian motion B and its time integral integral B d t. In this paper we construct successful co-adapted couplings for iterated Kolmogorov diffusions defined by adding ...
Wilfrid S. Kendall, Kendall, W. S., Price, Catherine J., Catherine J. Price   +3 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Fluid coupling between the elements in a discrete model of cochlear mechanics

, 2010
When analysing the coupled mechanics of the cochlea, due to the interaction between fluid coupling and basilar membrane motion, it is convenient to divide the cochlea longitudinally into a discrete number of sections.
Ni, G., Elliott, S.J., Lineton, B.
core   +1 more source

Design of polarization splitter using elliptically dual core – Cladding photonic crystal fiber

Results in Physics, 2019
In this work, the polarization splitter using dual-core elliptically cladding photonic crystal fiber is numerically investigated. The design features the polarization inducement with four distinct modes known as even and odd mode in X-polarization and Y ...
P. Muruganantham, J. Prakash, S. Vidyasagar, C.S. Boopathi, Iraj S. Amiri   +4 more
doaj   +1 more source