Results 61 to 70 of about 294,366 (259)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Experimental Demonstration of Geometric Tilt-to-Length Noise Model in Test Mass Interferometer

Sensors
Space-based gravitational wave detection missions impose extremely stringent requirements on the measurement precision of the laser interferometer, where tilt-to-length coupling noise emerges as a critical factor degrading performance. This paper focuses
Mengyang Zhao, Jia Shen, Shaoxin Wang, Keqi Qi, Heshan Liu, Peng Xu, Ruihong Gao, Ziren Luo   +7 more
doaj   +1 more source

The Transport Performance of Feedback Coupled Brownian Ratchets

MATEC Web of Conferences, 2017
The directed transport properties of feedback coupled Brownian ratchets under the effect of external periodic force and load force are investigated. The influence of the coupling strength on the transport properties of coupled system is discussed in ...
Fan LiMing, Lv MingTao, Huang RenZhong, Gao TianFu   +3 more
doaj   +1 more source

Coherence Length of Cold Exciton Gases in Coupled Quantum Wells [PDF]

Physical Review Letters, 2006
5 pages, 3 ...
Yang, Sen, Hammack, Aaron Tynes, Fogler, Michael M., Butov, Leonid V., Gossard, Arthur C.   +4 more
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The perfect waveguide coupler with universal impedance matching and transformation optics

Nanophotonics
Efficient energy transfer is crucial in electromagnetic communication. Therefore, producing a waveguide coupler that achieves broadband, nonreflective transmission is a challenging task. With the advancement of silicon-based integrated photonic circuits,
Kim Myeongjin, Park Q-Han
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Behaviour of Plate Anchorage in Plate-Reinforced Composite Coupling Beams

The Scientific World Journal, 2013
As a new alternative design, plate-reinforced composite (PRC) coupling beam achieves enhanced strength and ductility by embedding a vertical steel plate into a conventionally reinforced concrete (RC) coupling beam.
W. Y. Lam, Lingzhi Li, R. K. L. Su, H. J. Pam   +3 more
doaj   +1 more source

The evaluation of convectively coupled waves in limited-length datasets

Climate Dynamics
Abstract Organised tropical convection is strongly influenced by intraseasonal convectively coupled waves (CCWs), particularly Kelvin waves and the Madden-Julian Oscillation (MJO). Kilometre-scale models simulating deep convection explicitly offer new possibilities for investigating the multiscale dynamics of these waves.
Xu, Chang, Sherwood, Steven, Jucker, Martin, Lopez-Bravo, Clemente, Jones, Richard   +4 more
openaire   +1 more source