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Metabolic Networks of Longevity [PDF]

Cell, 2010
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health
Houtkooper Riekelt H, Williams Robert W, Auwerx Johan   +2 more
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Development and validation of diagnostic models for immunoglobulin A nephropathy based on gut microbes

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundImmunoglobulin A nephropathy (IgAN) is a highly prevalent glomerular disease. The diagnosis potential of the gut microbiome in IgAN has not been fully evaluated.
Yijun Dong, Yijun Dong, Jiaojiao Chen, Jiaojiao Chen, Yiding Zhang, Yiding Zhang, Zhihui Wang, Zhihui Wang, Jin Shang, Jin Shang, Jin Shang, Zhanzheng Zhao, Zhanzheng Zhao, Zhanzheng Zhao   +13 more
doaj   +1 more source

Nitrogen Uptake in Plants: The Plasma Membrane Root Transport Systems from a Physiological and Proteomic Perspective

Plants, 2021
Nitrogen nutrition in plants is a key determinant in crop productivity. The availability of nitrogen nutrients in the soil, both inorganic (nitrate and ammonium) and organic (urea and free amino acids), highly differs and influences plant physiology ...
Chiara Muratore, Luca Espen, Bhakti Prinsi   +2 more
doaj   +1 more source

Deciphering the physiological response of Escherichia coli under high ATP demand

Molecular Systems Biology, 2021
One long‐standing question in microbiology is how microbes buffer perturbations in energy metabolism. In this study, we systematically analyzed the impact of different levels of ATP demand in Escherichia coli under various conditions (aerobic and ...
Simon Boecker, Giulia Slaviero, Thorben Schramm, Witold Szymanski, Ralf Steuer, Hannes Link, Steffen Klamt   +6 more
doaj   +1 more source

Insights into the Antimicrobial Activities and Metabolomes of Aquimarina (Flavobacteriaceae, Bacteroidetes) Species from the Rare Marine Biosphere

Marine Drugs, 2022
Two novel natural products, the polyketide cuniculene and the peptide antibiotic aquimarin, were recently discovered from the marine bacterial genus Aquimarina.
Sandra Godinho Silva, Patrícia Paula, José Paulo da Silva, Dalila Mil-Homens, Miguel Cacho Teixeira, Arsénio Mendes Fialho, Rodrigo Costa, Tina Keller-Costa   +7 more
doaj   +1 more source

NetCom: A Network-Based Tool for Predicting Metabolic Activities of Microbial Communities Based on Interpretation of Metagenomics Data

Microorganisms, 2021
The study of microbial activity can be viewed as a triangle with three sides: environment (dominant resources in a specific habitat), community (species dictating a repertoire of metabolic conversions) and function (production and/or utilization of ...
Ofir Tal, Rotem Bartuv, Maria Vetcos, Shlomit Medina, Jiandong Jiang, Shiri Freilich   +5 more
doaj   +1 more source

METHOD OF JOINT CLUSTERING IN NETWORK AND CORRELATION SPACES [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2020
Subject of Research. The joint clustering method in network and correlation context is designed to identify active modules in metabolic graphs based on transcriptomic data represented by a large number of samples.
Anastasiia N. Gainullina, Maxim Artyomov, Alexey A. Sergushichev   +2 more
doaj   +1 more source

Use of a global metabolic network to curate organismal metabolic networks [PDF]

Scientific Reports, 2013
The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts.
A. R. Pah, R. Guimerà, A. M. Mustoe, L. A. N. Amaral   +3 more
openaire   +2 more sources

Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms

Metabolites, 2021
Genome-scale metabolic models (GEMs) are powerful tools for understanding metabolism from a systems-level perspective. However, GEMs in their most basic form fail to account for cellular regulation.
Carolina H. Chung, Da-Wei Lin, Alec Eames, Sriram Chandrasekaran   +3 more
doaj   +1 more source

Hybrid Metabolic Network Completion [PDF]

Theory and Practice of Logic Programming, 2017
AbstractMetabolic networks play a crucial role in biology since they capture all chemical reactions in an organism. While there are networks of high quality for many model organisms, networks for less studied organisms are often of poor quality and suffer from incompleteness.
Clémence Frioux, Torsten Schaub, Sebastian Schellhorn, Anne Siegel, Philipp Wanko   +4 more
openaire   +4 more sources