Results 31 to 40 of about 297,984 (312)

High-Performance Biocomputing in Synthetic Biology–Integrated Transcriptional and Metabolic Circuits

Frontiers in Bioengineering and Biotechnology, 2019
Biocomputing uses molecular biology parts as the hardware to implement computational devices. By following pre-defined rules, often hard-coded into biological systems, these devices are able to process inputs and return outputs—thus computing information.
Angel Goñi-Moreno, Pablo I. Nikel
doaj   +1 more source

Systematic assignment of thermodynamic constraints in metabolic network models [PDF]

, 2006
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are put into the automated reconstruction of such models.
Kümmel, Anne,, Anne Kümmel, Sven Panke, Matthias Heinemann, Heinemann, Matthias, Heinemann Matthias, Panke, Sven, Heinemann, Matthias,, Kümmel, Anne, Panke, Sven,, Panke Sven, Heinemann, Matthias; id_orcid, Kümmel Anne   +12 more
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Bayesian Integrative Modeling of Genome-Scale Metabolic and Regulatory Networks

Informatics, 2020
The integration of high-throughput data to build predictive computational models of cellular metabolism is a major challenge of systems biology. These models are needed to predict cellular responses to genetic and environmental perturbations.
Hanen Mhamdi, Jérémie Bourdon, Abdelhalim Larhlimi, Mourad Elloumi   +3 more
doaj   +1 more source

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition [PDF]

, 2011
The quantification of experimentally-induced alterations in biological pathways remains a major challenge in systems biology. One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex ...
Dawson, Neil, Xiaolin Xiao, Brian J Morris, Xiao, X., Higham, Desmond, MacIntyre, L., Pratt, J.A., Morris, Brian J., MacIntyre, Lynsey, Higham, Desmond J, Higham, D.J., Desmond J Higham, Watson, David, Neil Dawson, Watson, David G., Judith A Pratt, Xiao, Xiaolin, Morris, B.J., Pratt, Judith, David G Watson, Pratt, Judith A., Dawson, N., Lynsey MacIntyre, Watson, D.G., Morris, Brian   +24 more
core   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M., Eriko Takano (50986), Breitling, Rainer, Albert Gevorgyan, Gevorgyan, A., Breitling, R., Breitling, Rainer,, Andrzej M Kierzek, Zakrzewski, Piotr, Breitling Rainer, Gevorgyan Albert, Piotr Zakrzewski (111739), Piotr Zakrzewski, Rainer Breitling (4371), Eriko Takano, Medema, M.H., Takano, Eriko,, Zakrzewski Piotr, Gevorgyan, Albert, Takano Eriko, Kierzek, Andrzej M., Zakrzewski, P., Takano, E., Rainer Breitling, Medema Marnix H., Gevorgyan, Albert,, Marnix H. Medema (111741), Medema, Marnix H.,, Medema, Marnix H., Albert Gevorgyan (111745), Andrzej M. Kierzek (111748), Kierzek Andrzej M., Takano, Eriko, Zakrzewski, Piotr,, Marnix H Medema, Takano, Eriko; id_orcid, Kierzek, Andrzej M.,   +36 more
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Complex networks: the key to systems biology

Genetics and Molecular Biology, 2008
Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena.
Luciano da F. Costa, Francisco A. Rodrigues, Alexandre S. Cristino   +2 more
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METABOLIC NETWORKS ROBUSTNESS: THEORY, SIMULATIONS AND RESULTS [PDF]

, 2011
Metabolic networks are composed of several functional modules, reproducing metabolic pathways and describing the entire cellular metabolism of an organism.
Lanza, B, Conti, V, SORBELLO, Filippo, Cusumano, D, VITABILE, Salvatore   +4 more
core   +1 more source

The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM

Virulence, 2019
The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses.
Edvin J. Thanikkal, Dharmender K. Gahlot, Junfa Liu, Marcus Fredriksson Sundbom, Jyoti M. Gurung, Kristina Ruuth, Monika K. Francis, Ikenna R. Obi, Karl M. Thompson, Shiyun Chen, Petra Dersch, Matthew S. Francis   +11 more
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Multi-Omics Driven Metabolic Network Reconstruction and Analysis of Lignocellulosic Carbon Utilization in Rhodosporidium toruloides

Frontiers in Bioengineering and Biotechnology, 2021
An oleaginous yeast Rhodosporidium toruloides is a promising host for converting lignocellulosic biomass to bioproducts and biofuels. In this work, we performed multi-omics analysis of lignocellulosic carbon utilization in R. toruloides and reconstructed
Joonhoon Kim, Joonhoon Kim, Joonhoon Kim, Samuel T. Coradetti, Samuel T. Coradetti, Young-Mo Kim, Young-Mo Kim, Yuqian Gao, Yuqian Gao, Junko Yaegashi, Junko Yaegashi, Jeremy D. Zucker, Jeremy D. Zucker, Nathalie Munoz, Nathalie Munoz, Erika M. Zink, Kristin E. Burnum-Johnson, Kristin E. Burnum-Johnson, Scott E. Baker, Scott E. Baker, Scott E. Baker, Blake A. Simmons, Blake A. Simmons, Blake A. Simmons, Jeffrey M. Skerker, John M. Gladden, John M. Gladden, John M. Gladden, Jon K. Magnuson, Jon K. Magnuson, Jon K. Magnuson   +30 more
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Evolution of metabolic network organization [PDF]

BMC Systems Biology, 2010
Comparison of metabolic networks across species is a key to understanding how evolutionary pressures shape these networks. By selecting taxa representative of different lineages or lifestyles and using a comprehensive set of descriptors of the structure and complexity of their metabolic networks, one can highlight both qualitative and quantitative ...
Aurélien Mazurie, Danail Bonchev, Benno Schwikowski, Gregory A. Buck   +3 more
openaire   +4 more sources