Results 51 to 60 of about 282,038 (168)

Regulatory crosstalk of the metabolic network [PDF]

Trends in Biochemical Sciences, 2010
The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli and environmental conditions. Through monitoring by metabolite responsive macromolecules, metabolic pathways interact with the transcriptome and proteome.
Gruning, N., Lehrach, H., Ralser, M.
openaire   +3 more sources

Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community

Metabolites, 2019
The use of multiple omics techniques (i.e., genomics, transcriptomics, proteomics, and metabolomics) is becoming increasingly popular in all facets of life science.
Farhana R. Pinu, David J. Beale, Amy M. Paten, Konstantinos Kouremenos, Sanjay Swarup, Horst J. Schirra, David Wishart   +6 more
doaj   +1 more source

NetMet: A Network-Based Tool for Predicting Metabolic Capacities of Microbial Species and their Interactions

Microorganisms, 2020
Metabolic conversions allow organisms to produce a set of essential metabolites from the available nutrients in an environment, frequently requiring metabolic exchanges among co-inhabiting organisms.
Ofir Tal, Gopinath Selvaraj, Shlomit Medina, Shany Ofaim, Shiri Freilich   +4 more
doaj   +1 more source

A Novel Methodology to Estimate Metabolic Flux Distributions in Constraint-Based Models

Metabolites, 2013
Quite generally, constraint-based metabolic flux analysis describes the space of viable flux configurations for a metabolic network as a high-dimensional polytope defined by the linear constraints that enforce the balancing of production and consumption ...
Francesco Alessandro Massucci, Isaac Pérez Castillo, Andrea De Martino, Francesc Font-Clos   +3 more
doaj   +1 more source

Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in Salmonella enterica

Metabolites, 2019
In Salmonella enterica, 2-aminoacrylate (2AA) is a reactive enamine intermediate generated during a number of biochemical reactions. When the 2-iminobutanoate/2-iminopropanoate deaminase (RidA; EC: 3.5.99.10) is eliminated, 2AA accumulates and inhibits ...
Andrew J. Borchert, Jacquelyn M. Walejko, Adrien Le Guennec, Dustin C. Ernst, Arthur S. Edison, Diana M. Downs   +5 more
doaj   +1 more source

Development and applications of metabolic models in plant multi-omics research

Frontiers in Plant Science
Plant growth and development are characterized by systematic and continuous processes, each involving intricate metabolic coordination mechanisms.
Yonggang Gao, Cheng Zhao
doaj   +1 more source

A Statistical Thermodynamical Interpretation of Metabolism

Entropy, 2010
The metabolic network of a cell can be decomposed into discrete elementary modes that contribute, each with a certain probability, to the overall flux through the metabolism.
Pornkamol Unrean, Friedrich Srienc
doaj   +1 more source

Visual analysis of multi-omics data

Frontiers in Bioinformatics
We present a tool for multi-omics data analysis that enables simultaneous visualization of up to four types of omics data on organism-scale metabolic network diagrams.
Austin Swart, Ron Caspi, Suzanne Paley, Peter D. Karp   +3 more
doaj   +1 more source

How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation

Food Frontiers
‘Manicure Finger’ grape exhibits gradient coloration during veraison, where the lower part of the skin changes color faster and intenser than the upper, giving the same berry a gradient color from green on the top to red on the bottom.
Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma   +7 more
doaj   +1 more source

Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth

Frontiers in Microbiology, 2019
Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling.
Alvaro Fuertes, Alvaro Fuertes, Sergio Pérez-Burillo, Iñigo Apaolaza, Iñigo Apaolaza, Yvonne Vallès, Yvonne Vallès, M. Pilar Francino, M. Pilar Francino, José Ángel Rufián-Henares, José Ángel Rufián-Henares, Francisco J. Planes, Francisco J. Planes   +12 more
doaj   +1 more source