Results 51 to 60 of about 297,984 (312)
Universal fractal scaling of self-organized networks [PDF]
, 2010 There is an abundance of literature on complex networks describing a variety of relationships among units in social, biological, and technological systems.
Qawi K. Telesford +4 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Ensemble Modeling of Metabolic Networks [PDF]
Biophysical Journal, 2008 Complete modeling of metabolic networks is desirable, but it is difficult to accomplish because of the lack of kinetics. As a step toward this goal, we have developed an approach to build an ensemble of dynamic models that reach the same steady state.
Tran, Linh M. +2 more
openaire +2 more sources
Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks [PDF]
, 2017 The increasing availability of large metabolomics datasets enhances the need for computational methodologies that can organize the data in a way that can lead to the inference of meaningful relationships.
Hatzimanikatis, V. +3 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2021 Because of its ability to generate biological hypotheses, metabolomics offers an innovative and promising approach in many fields, including clinical research. However, collecting specimens in this setting can be difficult to standardize, especially when
Julien Boccard +11 more
doaj +1 more source
Essentiality Landscape of Metabolic Networks [PDF]
Journal of the Korean Physical Society, 2019 Local perturbations of individual metabolic reactions may result in different levels of lethality, depending on their roles in metabolism and the size of subsequent cascades induced by their failure. Moreover, essentiality of individual metabolic reactions may show large variations within and across species.
Kim, P., Han, K., Lee, D. -S., Kahng, B.
openaire +2 more sources
Identification of flux control in metabolic networks using non-equilibrium thermodynamics [PDF]
, 2010 A method is presented to identify flux controlling reactions in metabolic networks using experimentally determined flux distributions. The method is based on the application of Ziegler\u27s principle for the maximization of entropy production.
Velasco, Sergio +3 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Optimization strategies for metabolic networks [PDF]
BMC Systems Biology, 2009 Abstract Background The increasing availability of models and data for metabolic networks poses new challenges in what concerns optimization for biological systems. Due to the high level of complexity and uncertainty associated to these networks the suggested models often lack detail and liability, required to ...
Alexandre Domingues +2 more
openaire +3 more sources