Results 61 to 70 of about 282,038 (168)

Mathematical analysis of metabolic networks

FEBS Letters, 1974
Although its important reaction sequences and cycles have been known for more than 25 years, we are still far from a satisfactory theory of intermediary metabolism. The empirical material is overwhelming and increases every year, but the development of a general conception is still in its infancy, although the conceptual progress of recent years has ...
Reich, J.G., Sel'kov, E.E.
openaire   +2 more sources

Diabetes Therapeutics Beyond Hyperglycaemia: Toward Biological Systems Redesign

Biomedicines
Diabetes pharmacology has historically been dominated by a glucose-centric framework in which therapeutic efficacy is defined primarily by reduction in blood glucose and glycated haemoglobin (HbA1c).
Solomon Habtemariam
doaj   +1 more source

Microbial Pathway Thermodynamics: Stoichiometric Models Unveil Anabolic and Catabolic Processes

Life
The biotechnological exploitation of microorganisms enables the use of metabolism for the production of economically valuable substances, such as drugs or food.
Oliver Ebenhöh, Josha Ebeling, Ronja Meyer, Fabian Pohlkotte, Tim Nies   +4 more
doaj   +1 more source

Evolution at the Origins of Life?

Life
The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common ...
Ludo L. J. Schoenmakers, Thomas A. C. Reydon, Andreas Kirschning   +2 more
doaj   +1 more source

COBRA methods and metabolic drug targets in cancer

Molecular & Cellular Oncology, 2018
The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis ...
Iñigo Apaolaza, Edurne San José-Eneriz, Xabier Agirre, Felipe Prósper, Francisco J. Planes   +4 more
doaj   +1 more source

Combining Knowledge About Metabolic Networks and Single-Cell Data with Maximum Entropy

Physical Sciences Forum
Better understanding of the fitness and flexibility of microbial platform organisms is central to biotechnological process development. Live-cell experiments uncover the phenotypic heterogeneity of living cells, emerging even within isogenic cell ...
Carola S. Heinzel, Johann F. Jadebeck, Elisabeth Zelle, Johannes Seiffarth, Katharina Nöh   +4 more
doaj   +1 more source

Topological and Functional Diversity of Gut Microbiota Metabolism Across the Human Lifespan

Metabolites
Background: The human gut microbiota plays a central role in host physiology by influencing digestion, immune function, and metabolism. Characterizing age-associated differences in the organization of microbial metabolism may provide insights into ...
Benjamí Pérez-Rocher, Mariana Reyes-Prieto, Susana Ruiz-Ruiz, Pere Palmer-Rodríguez, José Aurelio Castro, Andrés Moya, Mercè Llabrés-Segura   +6 more
doaj   +1 more source

A flexible view of metabolic network [PDF]

BMC Systems Biology, 2007
Ko-Yun Lo, Andrew R. Dalby
openaire   +1 more source

NAViFluX: a visualization‑centric platform for interactive analysis, refinement and design of genome‑scale metabolic networks. [PDF]

Bioinformatics
Krishnamurthy MB, Harish PS, Subramanian A.   +2 more
europepmc   +1 more source

AI-driven integration and optimization of medicinal plant multi-omics metabolic networks. [PDF]

Front Plant Sci
Chen J, Cai J, To Quyen Duong H, Bunsupa S, Han R, Tong X.   +5 more
europepmc   +1 more source